2-Aminothiazole is white or light yellow crystals. The melting point is 93°C and the boiling point is 140°C (1.47kPa). It is soluble in hot water, dilute hydrochloric acid and 20% sulfuric acid, and slightly soluble in cold water, ethanol and ether.

Uses of 2-Aminothiazole:

1. 2-Aminothiazole is used as a pharmaceutical intermediate for organic synthesis. 2-Aminothiazole is mainly used in the synthesis of Nitrosulfathiazole, Sulfathiazole, Sulfasuxidinum, Carbothiazol, Phthalylsulfathiazole, Oxyquinolinephthalysulfathiazole ), Salazosulfathiazole (Salazosulfathiazole)

2. 2-Aminothiazole is used for gentle Ulmann coupling reaction with 2-chlorobenzoic acid under the guidance of ultrasonic radiation

3. 2-Aminothiazole is used as a pharmaceutical and dye intermediate

Production method of 2-aminothiazole:

2-Aminothiazole is obtained by cyclization of thiourea and chloroacetaldehyde (or ethanol and chlorine, or α, β dichloro ethyl ether). Add hot water, thiourea and α, β-dichloroethyl ether to the reactor. Reflux for 2h under stirring. After cooling, sodium hydroxide solution was added through the dropping funnel to make the solution alkaline and 2-aminothiazole crystals were precipitated. Then add ether to dissolve it. Separate the ether layer, wash with water, dry with anhydrous sodium sulfate, and distill the ether to obtain a crude product. Recrystallize with ethanol to obtain yellow crystals. The yield is 80%, and the melting point is 90°C.

Toxicity classification: Highly toxic acute toxicity oral-rat LD50: 480 mg/kg; intraperitoneal-mouse LD50: 200 mg/kg

Hazardous characteristics of explosives: its nitric acid mixture; or its nitric acid-sulfuric acid mixture heating and exploding

Flammability and hazard characteristics: 2-Aminothiazole is combustible; high temperature produces toxic nitrogen oxide and sulfur oxide fumes

Storage and transportation characteristics: The warehouse is ventilated, low temperature and dry; stored separately from nitric acid and sulfuric acid

Extinguishing agent: dry powder, foam, sand, carbon dioxide, water mist

Clent Chemical is a supplier of 2-aminothiazole, we have professional technology to ensure product quality. If you want to know more about 2-aminothiazole, please continue to pay attention to our website. We will regularly update articles and information related to 2-aminothiazole, and look forward to your visit and consultation.