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A 2017 study in the journal Pain examined the effects of CBD in male rats with osteoarthritis. After two weeks, acute inflammation of the joints was reduced by local CBD treatment applied to the area. The administration of CBD was also found to prevent the development of nerve damage and joint pain. Chronic inflammation refers to a prolonged inflammatory response in the body. When inflammation lingers, it can detrimentally impact tissues and organs due to the increased production of free radicals, which results in oxidative stress, an imbalance between antioxidants and free radicals.