Maltodextrin's high GI indicates it can produce blood sugar increases, especially if ingested in large amounts. As a result, if you have diabetes or insulin resistance, you may wish to avoid or limit it. It should also be avoided if you have a family history of diabetes.  Another reason to minimise maltodextrin is to maintain healthy gut microbes. Maltodextrin, according to a 2012 study published in PLoS ONE, can alter the composition of your gut bacteria, making you more prone to disease.

It has the potential to inhibit the growth of probiotics in your digestive system, which are essential for immune system function. The same study found that Maltodextrin can promote the growth of germs like E. coli, which has been linked to autoimmune diseases including Crohn's disease. If you are at danger of developing an autoimmune or digestive issue, you should avoid maltodextrin.

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