The discovery that arthritic conditions resulted in a decrease in hyaluronan's average molecular weight and concentration led to the development of the therapeutic paradigm known as Europe Viscosupplementation for the long-term relief of pain in human and animal joints with osteoarthritis or traumatic arthritis. As a result, the synovial fluid's elastoviscous qualities are significantly diminished. Europe Viscosupplementation is a therapeutic process in which the pathological synovial fluid or effusion is removed from the joint by arthrocentesis and is replaced with a highly purified hyaluronan solution which has a 16- to 30-times greater concentration than the pathological joint fluid, and a 2- to 5-times greater concentration than that of the hyaluronan in the healthy synovial fluid.

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