Psychedelic-assisted therapy is another innovative approach to treating TRD. This approach involves the use of psychedelic substances such as psilocybin, MDMA, and ketamine in combination with psychotherapy. The use of these substances is tightly controlled and supervised by trained therapists in a clinical setting. Psychedelic-assisted therapy has shown promising results in treating a range of mental health conditions, including depression, anxiety, and PTSD. The therapy works by helping patients to access difficult emotions and memories in a safe and controlled environment Treatment Resistant Depression. This can lead to breakthroughs in therapy that may not be possible with traditional treatments. While psychedelic-assisted therapy is still in its early stages, the results have been encouraging, and many experts believe it has the potential to revolutionize mental health treatment.