Hemophilia affects about one in every 5,617 live male births, according to the US Centers for Disease Control and Prevention (CDC). In the United States, between 30,000 and 33,000 men have hemophilia. 

The severe type of hemophilia A affects more than half of those diagnosed. Hemophilia an affects four times more people than hemophilia B. Hemophilia is a blood disorder that affects people of all races and ethnicities. Hemophilia A, commonly known as classical hemophilia, is a genetic bleeding illness caused by a lack of factor VIII in the blood.

Data Bridge Market Research analyses that the Hemophilia a Treatment Market was valued at USD 11.1 billion in 2021 and is expected to reach USD 17.77 billion by 2029, registering a CAGR of 6.06% during the forecast period of 2022 to 2029. The market report curated by the Data Bridge Market Research team includes in-depth expert analysis, patient epidemiology, pipeline analysis, pricing analysis, and regulatory framework.

Hemophilia A is an inherited bleeding disorder that causes blood to coagulate abnormally. People with hemophilia A will bleed more than usual after an injury, surgery, or dental procedure. Hemophilia A is caused by a protein called factor VIII being deficient. Replacement therapy is the most common treatment in which clotting factor VIII is gently dripped or injected into a vein. Emicizumab is presently the only licensed nonfactor therapy that helps with venous access difficulties, frequent bleeds, and other issues, according to the National Center for Biotechnology Information (NCBI).

This treatment is also recommended to prevent bleeding in individuals taking inhibitors and having surgery. Following recent improvements, these new medicines show potential hemostatic qualities and enable considerable decreases in bleeding episodes in hemophilia patients with or without inhibitors. DDAVP (desmopressin acetate) is a synthetic version of vasopressin. This natural antidiuretic hormone helps to halt bleeding because of its clinical efficacy and safety and the availability of a concentrated formulation for intravenous and nasal administration.

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Hemophilia A Treatment Market Dynamics

Drivers

·       High prevalence rate of hemophilia across the globe

The rise in prevalence rate of hemophilia across the globe will act as a major driver that will result in the expansion of the market's growth rate. Patients with severe hemophilia require a frequent hemophilia treatment regimen to keep enough clotting factors in their bloodstream to avoid bleeds. Including a global study published in October 2021 by the World Federation of Hemophilia, there were 209,614 persons diagnosed with hemophilia worldwide, with 165,379 hemophilia A patients. Furthermore, patients who receive quality care are more likely to have fewer co-morbid diseases and have a decreased risk of serious bleeding. As a result, the ever-increasing number of patients has increased demand for haemophilia therapy, which will raise product adoption rates.

·       Surging number of pediatric population

The increasing number of pediatric population is estimated to enhance the market's growth rate during the forecast period of 2022-2029. The prevalence of hemophilia is steadily rising among pediatric. Hemophilia is expected to affect one out of every 10,000 births, according to the World Federation of Hemophilia (WFH). Pediatric with hemophilia lack enough clotting factors in their blood as they cannot stop bleeding, necessitating the use of specific hemophilia medications to prevent excessive bleeding. A number of government and non-government groups are launching public awareness campaigns about the signs, diagnosis, and treatment of hemophilia in pediatrics. Furthermore, prominent industry players are focusing on developing innovative solutions to minimize the severity of hemophilia in pediatrics, hence accelerating market growth.

Furthermore, rising initiatives by public and private organizations to spread awareness will expand the hemophilia A treatment market. Additionally, changing lifestyle of people and growing government favourable initiatives will result in the expansion of hemophilia A treatment market. Another significant factor influencing the growth rate of hemophilia A treatment market is the rising healthcare expenditure which helps in improving its infrastructure.

Opportunities

·       Increase in the number of research and development activities      

Moreover, the market's growth is fueled by an increase in the number of research and development activities. This will provide beneficial opportunities for the hemophilia A treatment market growth. BioMarin Pharmaceutical Inc. stated in 2021 that it had completed a large phase 3 gene therapy trial in adults with severe hemophilia A in the United States. Over the projection period, such continuous research and innovation initiatives are expected to boost market demand. As a result, the variables listed above are expected to boost product uptake in the country.

·       New product launches

Over the projected period, new product launches by industry players in the hemophilia A treatment market are estimated to promote new market opportunities. For illustration, the European Commission granted Novo Nordisk marketing approval for 'Esperoct' in Europe in June 2019. Turoctocog alfa pegol, N8-GP, is marketed under the trade name Esperoct and is used to treat hemophilia A in adolescents and adults (congenital factor VIII deficiency). Furthermore, Roche Products India Pvt. Ltd released Hemlibra, a hemophilia A medication, in India in April 2019. Through Factor VIII inhibitors, it is suggested for preventative therapy of hemophilia A patients to reduce the frequency of bleeding episodes.

Global Hemophilia A Treatment Market Scope

The hemophilia A treatment market is segmented on the basis of type, product, demographic, treatment, diagnosis, therapy, drug class, dosage form, route of administration, end-users and distribution channel. The growth amongst these segments will help you analyze meagre growth segments in the industries and provide the users with a valuable market overview and market insights to help them make strategic decisions for identifying core market applications.

Type

·       Severe

·       Moderate

·       Mild

Product

Recombinant Factor Concentrates

·       Factor VIII

·       Factor IX

Plasma-derived Factor Concentrates

·       Factor VIII

·       Factor IX

Extended Half-life Products

·       Factor VIII

·       Factor IX

Demographic

Pediatric

·       0 to 4

·       5 to 13

·       14 to18

Adult

·       19 to 44

·       45+

Diagnosis

·       Genetic Testing

·       Fibrinogen Test

·       Factor VIII and Factor IX Tests

·       Prothrombin Time (PT)

·       Complete Blood Count (CBC)

Treatment

·       Prophylaxis

·       On Demand

Therapy

·       Factor Replacement Therapy

·       Non-factor Replacement Therapy

Drug Class

·       Vasopressin

·       Coagulation Factors

Dosage Form

·       Injection

·       Solutions

·       Others

Route of Administration

·       Parenteral

·       Nasal Spray

·       Others

End-Users

·       Hospitals

·       Specialty Clinics

·       Homecare

·       Others

Distribution Channel

·       Hospital Pharmacy

·       Retail Pharmacy

·       Online Pharmacy

·       Others

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Hemophilia A Treatment Market Regional Analysis/Insights

The hemophilia A treatment market is analysed and market size insights and trends are provided by country, type, product, demographic, treatment, diagnosis, therapy, drug class, dosage form, route of administration, end-users and distribution channel as referenced above.

The countries covered in the hemophilia A treatment market report are U.S., Canada and Mexico in North America, Germany, France, U.K., Netherlands, Switzerland, Belgium, Russia, Italy, Spain, Turkey, Rest of Europe in Europe, China, Japan, India, South Korea, Singapore, Malaysia, Australia, Thailand, Indonesia, Philippines, Rest of Asia-Pacific (APAC) in the Asia-Pacific (APAC), Saudi Arabia, U.A.E, South Africa, Egypt, Israel, Rest of Middle East and Africa (MEA) as a part of Middle East and Africa (MEA), Brazil, Argentina and Rest of South America as part of South America

North America dominates the hemophilia A treatment market in terms of market share and market revenue and will continue to flourish its dominance during the forecast period. This is due to the presence of major key players, and rising healthcare expenditure will further propel the market's growth rate in this region. Additionally, increasing research and development activities will further propel the market's growth rate in this region.

Asia-Pacific is expected to grow during the forecast period of 2022-2029 due to rising approval of novel therapeutics for hemophilia A in this region. Also, the development of healthcare infrastructure and growing government initiatives will further propel the market's growth rate in this region.

The country section of the report also provides individual market impacting factors and changes in regulation in the market domestically that impacts the current and future trends of the market. Data points like down-stream and upstream value chain analysis, technical trends and porter's five forces analysis, case studies are some of the pointers used to forecast the market scenario for individual countries. Also, the presence and availability of global brands and their challenges faced due to large or scarce competition from local and domestic brands, impact of domestic tariffs and trade routes are considered while providing forecast analysis of the country data.  

Some of the major players operating in the hemophilia A treatment market are:

·       Pfizer Inc. (US)

·       GlaxoSmithKline plc (UK)

·       Novartis AG (Switzerland)

·       Mylan N.V. (US)

·       Teva Pharmaceutical Industries Ltd. (Israel)

·       Sanofi (France)

·       AstraZeneca (UK)

·       Johnson & Johnson Private Limited (US)

·       Merck & Co., Inc. (US)

·       F. Hoffmann-La Roche Ltd. (Switzerland)

·       Baxter (US)

·       Takeda Pharmaceutical Company Limited (Japan)

·       Grifols, S.A. (Spain)

·       CSL (US)

·       BioMarin (US)

·       Spark Therapeutics, Inc. (US)

·       Chugai Pharmaceutical Co. Ltd. (Japan)

·       Octapharma AG (Switzerland)

·       Novo Nordisk A/S (Denmark)

·       Biogen (US)

·       Genentech Inc. (US)

·       Bayer AG (Germany)

·       Ferring B.V. (Switzerland)

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