It is important to note that Hydroxychloroquine is generally considered to be a safe medication when used at appropriate doses. However, like any medication, it can have potential side effects. The most concerning side effect is retinopathy, which is rare but can be irreversible and lead to vision loss. Regular ophthalmologic monitoring is recommended for patients on long-term hydroxychloroquine therapy.

Hydroxychloroquine has been investigated as a potential disease-modifying agent in PsA due to its immunomodulatory properties. However, current evidence does not support its routine use in PsA, as recent randomized controlled trials have failed to demonstrate significant clinical benefits. Nonetheless, individual patients may still benefit from hydroxychloroquine treatment, and its use should be evaluated on a case-by-case basis. Further research is needed to better understand the optimal role of hydroxychloroquine in the management of PsA and to identify subgroups of patients who may benefit from it.

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