Diablo 2 Resurrected's new v2.4 patch is expected to change the metadata with a slew of new rune words, character rebalances, and gear tweaks.
Of the known rune words, a remake of the plague has been identified. The Plague order has been changed to Cham + Shael + Um, but a new use for the underutilized Cham D2R Runes. The new version of Plague has everyone trying to figure out why you should use Plague instead of something like Hoto, or even a powerful melee weapon like Sorrow or Dying Breath.
The biggest change is that Plague now uses a 3-socket sword instead of a normal weapon. Another change is that all skills are -1 and +strength has been removed as Fal is no longer used. Added boost damage, which is a big bonus to raw damage. Other data are basically the same.
The use of the plague may be the spellcaster. If you can do this in a scepter, imagine a +3 Heaven's Fist scepter where you roll a plague, giving you a cleansing aura and bonus skill points; again to motivate something other than Hoto. Assuming you get +3 Trap Light Sentinel or +3 Death Sentinel Claw, you can roll Plague, get +4 Trap, Purify Aura - again, more incentive to use something other than Hoto.
Besides, RPGStash is an MMORPG supplier, if you are tired of repeatedly planting runes, you can quickly buy d2r runes from RPGStash.com, you can even Buy D2R Ladder Items directly, which is very fast and enjoyable.