The most common cause of these Syndrome is surgical intervention. It may occur as a result of bowel resection due to conditions such as Crohn's disease, intestinal tumors, mesenteric ischemia, or traumatic injury. Additionally, congenital defects or diseases like volvulus or gastroschisis can also lead to a short bowel.

The severity of Short Bowel Syndrome largely depends on the length of the remaining small intestine. Typically, if more than half of the small intestine is removed or damaged, it can result in a higher risk of complications. With reduced surface area for absorption, essential nutrients like carbohydrates, proteins, fats, vitamins, and minerals are not adequately absorbed, leading to malnutrition and various deficiencies.