Ethyl acetate increases toxicity when combined with certain other chemicals, such as morpholine, ethylene glycol, or ethanol. Eu Harmonized GHS classification: EUH066- Repeated exposure may cause dryness or cracking of the skin. 

Ethyl acetate (ethyl acetate sds) was negative in 36 mutagenicity studies.

Flammability: Ethyl acetate has a flash point of 24F (-4C), causing occupational safety problems. The SAB points to this as a key issue. 

The National Fire Protection Association (NFPA) classifies it as an flammability rating of 3 (Note: NFPA has a rating of 0 (non-combustible) to 4 (extremely flammable liquid), which includes "materials that ignite easily under almost all normal temperature conditions." Water may not be able to control or extinguish fires in such materials." 

Eu harmonised classification under the Globally Harmonised System: Hazard Class 2 Flammable liquids (flash point <23℃, initial boiling point >35℃; Note: GHS has 3 classes of flammable liquids, of which 1 class is the highest flammability); H225: Highly flammable liquids and vapors. 

Ethyl acetate caused accidents because of its flammability. In 2008, for example, an electrostatic spark ignited ethyl acetate, destroying a warehouse and requiring the evacuation of nearby businesses.

Reactivity and explosive: 

Ethyl acetate reacts violently with some chemicals and explosively with others, such as lithium tetrahydroaluminate.

According to the EPA's PBT profiler, it has low persistence in water and soil, moderate persistence in sediment, high persistence in air, and is toxic to fish.

Ethyl acetate has a high vapor pressure of 93 mm Hg at 25 degrees Celsius, indicating that it is most likely present in the air as a vapor. The half-life in the air is estimated to be 10 days. 16

Ethyl acetate is a volatile organic compound that causes photochemical smog when emitted into the air.