Leishmaniasis is a parasitic disease caused by protozoa of the genus Leishmania. The disease can affect skin, mucosal tissues, and visceral organs. Symptoms vary depending on the parasite species and the infected organ. Cutaneous leishmaniasis causes skin sores, while visceral leishmaniasis affects internal organs. If left untreated, visceral leishmaniasis can be fatal. Treatment options include pentavalent antimonials, miltefosine, amphotericin B, and paromomycin. The global Leishmaniasis Treatment Market is estimated to be valued at US$ 79.95 Bn in 2024 and is expected to exhibit a CAGR of 22% over the forecast period 2024 to 2031, as highlighted in a new report published by Coherent Market Insights.

Market Dynamics:

One of the primary drivers fueling growth of the Global Leishmaniasis Treatment Market Size is increasing prevalence of leishmaniasis globally. Around 1 million new cases of leishmaniasis occur annually. The disease is endemic in tropical and subtropical regions of Africa, Asia, Europe, and South America. According to the World Health Organization (WHO), 90% of global visceral leishmaniasis cases occur in just six countries namely Bangladesh, Brazil, Ethiopia, India, South Sudan, and Sudan. Additionally, new endemic regions are emerging due to deforestation, construction of dams and irrigation systems, urbanization, and migration of non-immune people. These factors have boosted transmission of parasites and increased the risk of disease spread. For instance, leishmaniasis is increasingly being reported in areas such as Sub-Saharan Africa that were traditionally non-endemic. Thus growing disease prevalence worldwide is driving demand for leishmaniasis treatments in the market.

Growing disease prevalence is primarily driven by factors such as increasing transmission of parasites due to environmental changes, migration, and changing demographic trends. Current treatment options are inadequate owing to toxicity, long treatment duration, emerging resistance, and need for skilled administration. These factors indicate a need for more effective and easy to use treatment alternatives in the market. This subsequently presents lucrative growth opportunities for players in the leishmaniasis treatment market during the forecast period.

SWOT Analysis

Strength: The Leishmaniasis Treatment market has significant unmet medical needs as there are currently no approved drugs for leishmaniasis treatment in many regions. The governments of several countries have recognized leishmaniasis as a public health problem, which is encouraging more research and development in this market. There have been substantial investments from public and private organizations to develop new drugs and vaccines for leishmaniasis treatment.

Weakness: Developing drugs for leishmaniasis faces various challenges as the parasites have complex life cycles with different infective forms in the insect vector and the human host. Achieving a balance between efficacy, safety, tolerability and cost-effectiveness is difficult. There are also concerns regarding drug resistance with current treatments.

Opportunity: The market has opportunities to develop new drug formulations, drug delivery systems and combination therapies to improve treatment outcomes. As the disease is prevalent in developing countries, opportunities exist for affordable drugs and vaccines. Developing countries with a high burden also provide platforms for clinical trials to evaluate new treatment regimens.

Threats: Competing priorities and limited funding for neglected tropical diseases can be a threat. Economic and political instability in endemic regions may hamper clinical research. Environmental changes promoting the spread of the vector could increase disease prevalence, threatening control and elimination efforts. Generic competition can erode sales of newly launched branded drugs.

Key Takeaways

The global Leishmaniasis Treatment market is expected to witness high growth over the forecast period of 2024 to 2031. The market size is anticipated to reach US$ 79.95 billion by 2024 at a CAGR of 22%.

Regional analysis indicates that South America accounts for the largest market currently due to high disease burden countries like Brazil and Peru located in this region. However, the Middle East and Asia Pacific regions are anticipated to be the fastest growing market for Leishmaniasis Treatment over the forecast period.

Key players operating in the Leishmaniasis Treatment market include Johnson & Johnson, Intrabio, Cyclo Therapeutics, Inc., Kempharm, Inc., Azafaros B.V., and Sarepta Therapeutics, Inc. These players are focused on developing novel therapies to treat disease manifestations. For instance, Johnson & Johnson is conducting phase 2 trials of Oravec (Fomivirsen) for mucocutaneous leishmaniasis treatment. Intrabio is developing oral carbamic derivatives for visceral leishmaniasis. Cyclo Therapeutics is evaluating trehalose for visceral leishmaniasis.

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