Epilepsy is one of the main conditions where Vagus Nerve Stimulators has shown effectiveness. Multiple clinical trials found that VNS reduced seizure frequency in about half of patients who did not respond well to seizure medications alone. It typically takes a few months after implantation for VNS to reach its full effect. Studies have found 30-50% of patients experience a 50% or greater decrease in seizures, with 10-20% becoming seizure-free. VNS may also reduce seizure severity and improve quality of life for many who receive it. It has been approved by the FDA as an adjunctive treatment for epilepsy.

VNS has revolutionized epilepsy treatment over the past few decades by providing effective seizure control for a subgroup of patients previously thought untreatable. Beyond epilepsy, promising research now expands its prospects into new terrain of depression, Alzheimer's, migraines, and more. With ongoing progress, VNS may evolve into a frontline therapy rather than a last resort for many brain-based conditions. Its calming influence on neural hyperactivity holds much future promise.

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