Studies on the Membrane Proteins of H. pylori

Posted 2024-03-06 06:54:50

The membrane proteins (MPs) of H. pylori (especially adhesins) are essential for colonization, survival, pathogenesis, and cause inflammatory responses. Ace Infectious provides research services on H. pylori MPs to help discover vaccine development solutions and drug therapy targets.

Fig. 1 H. pylori membrane proteins include outer and inner membrane proteins

The MPs of H. pylori are well worth studying. The MPs of H. pylori play an important role in its survival in the stomach. For example, the adhesion properties of the adhesin BabA vary with pH, which allows H. pylori to survive by adapting to gastric pH changes and adhering to gastric cells at the right time. Then, the MPs of H. pylori are also associated with the pathogenicity of H. pylori and causing inflammatory responses. SabA-positive Western strains of H. pylori can cause intestinal metaplasia, gastric cancer, and corpuscular atrophy. Deletion of AlpA and AlpB in H. pylori East Asian strains reduces IL-8 secretion. What’s more, various pore proteins in the cell membrane of H. pylori have a role in the physiological homeostasis and resistance to antibiotics.

Services overview

Ace Infectious offers research services for H. pylori adhesins and other MPs.

Research services for H. pylori adhesins

We offer two services related to the adhesion of H. pylori adhesins. They are adhesion site studies and adhesion properties studies. For adhesion site studies, we can provide partial amino acid substitution of adhesins to find precise adhesion sites. For adhesion properties studies, we mainly provide detection of adhesion properties changing under different environmental conditions. In addition, we also provide studies on the regulated expression of adhesins, the immune response induced by adhesins, and the pathogenic effects of adhesins.

Learn more：H. pylori MP

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