What are the Best Places To Stay in The Keys?For an unforgettable trip to the Florida Keys, these accommodations promise the perfect stay. In lively Key West, The Marquesa Hotel offers boutique luxury, while The Perry Hotel Key West charms with its waterfront setting. In serene Islamorada, The Moorings Village boasts cozy beachfront cottages, and Cheeca Lodge & Spa elevates relaxation with upscale amenities. Marathon offers family-friendly comfort at Tranquility Bay Beach House Resort and indulgent luxury at Isla Bella Beach Resort. Key Largo entices with beachfront bliss at Playa Largo Resort & Spa or all-inclusive relaxation at Bungalows Key Largo. For a nature-centric getaway, head to Big Pine Key, where Deer Run Bed & Breakfast immerses you in lush greenery, or opt for a historic stay with outdoor adventures at The Barnacle Bed and Breakfast.