Blood Plasma Derivatives: Important Life-Saving Products From Plasma Fractionation
Blood plasma is the liquid component of blood that remains after red blood cells, white blood cells, platelets and other cellular components are removed. Plasma fractionation is the process of separating the various therapeutic products from donated human plasma through specific laboratory or industrial processes. This process yields blood plasma derivatives that can be used to manufacture important biopharmaceutical products used in treating several medical conditions.
Albumin
One of the main Blood Plasma Derivatives obtained is albumin, which is the most abundant protein in blood plasma. Albumin plays an important role in regulating blood pressure by maintaining oncotic pressure in the blood vessels. It is also involved in transporting medications, hormones, vitamins and minerals throughout the body. Purified plasma-derived albumin is commonly used to treat conditions characterized by abnormally low albumin levels like cirrhosis, burns and nephrotic syndrome. It is also administered during complex surgical procedures to replace lost fluids and proteins.
Immunoglobulins
Plasma fractionation also yields immunoglobulins or antibodies, the main classes being IgG, IgA and IgM. Purified immunoglobulin concentrates prepared from donated plasma are prescribed for treating patients with impaired antibody production and recurrent infections. Intravenous immunoglobulin (IVIG) is an essential treatment for patients with primary immunodeficiencies and certain autoimmune disorders. It provides immediate protection against infections till the patient's own immune system recovers. Subcutaneous immunoglobulin therapy is also available for long-term antibody replacement.
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