mRNA Synthesis Raw Materials Industry

The global mRNA synthesis raw materials market was valued at USD 1.72 billion in 2023, with a projected compound annual growth rate (CAGR) of 2.85% from 2024 to 2030. mRNA synthesis occurs through the process of transcription within the nucleus, using a DNA nucleotide sequence as a template. This process involves several stages, including initiation, elongation, editing, and termination. mRNA synthesis has broad applications in fields such as drug discovery, vaccine development, and therapeutic manufacturing. RNA-based vaccines, in particular, offer notable benefits including better immunogenicity, higher efficiency, and faster production times. These factors, along with growing academic and industrial interest in mRNA technology and increasing funding for research, are driving the market's growth.

A significant milestone in mRNA vaccine development occurred in March 2020, when the National Institute of Allergy & Infectious Diseases (NIAID) and Moderna, Inc. co-developed mRNA-1273, a vaccine with 94.1% efficacy in preventing symptomatic COVID-19. In December 2020, this vaccine received emergency use authorization from the U.S. Food & Drug Administration (FDA), leading to a dramatic increase in the use of mRNA vaccines during the pandemic. This surge in demand showcased the potential of mRNA technology, significantly boosting market growth.

In recent years, RNA research centers have been established at several prestigious institutions to explore the therapeutic potential of RNA, particularly in vitro transcribed (IVT) mRNA. Examples include the Yale Center for RNA Science and Medicine, the RNA Institute at the University of Albany, and the RNA Therapeutic Institute at the University of Massachusetts. Additionally, university spin-off companies, backed by substantial venture capital investments, have accelerated the preclinical and clinical development of mRNA-based therapeutics. Companies such as Argos Medicines, Factor Bioscience, CureVac, Ethris, BioNTech, Moderna, eTheRNA, and Onkaido have been at the forefront of these advancements. As academic and industrial interest in mRNA technology continues to grow, the demand for mRNA synthesis raw materials is expected to increase, further propelling market growth.

Gather more insights about the market drivers, restrains and growth of the mRNA Synthesis Raw Materials Market

Type Insights

Capping Agents Segment Leading the Market (2023):

• In 2023, the capping agents segment held the largest revenue share of 39.17% in the global mRNA synthesis raw materials market.
• Capping and tailing are critical steps in producing active mRNA for functional studies, especially in eukaryotic cells where these processes help prevent mRNA degradation and enhance translation.
• Capping agents act as binding molecules or stabilizers, preventing steric hindrance or agglomeration during mRNA synthesis.
• The essential role of capping agents in ensuring the stability and functionality of mRNA is a key factor driving the growth of this segment.

Fastest CAGR for Capping Agents (2024-2030):

• The capping agents segment is expected to expand at the fastest compound annual growth rate (CAGR) of 3.26% over the forecast period from 2024 to 2030.
• This rapid growth is largely due to the development of modern alternatives to traditional enzymatic capping methods used in mRNA synthesis.
• Major market players are innovating new capping technologies to support the production of mRNA therapeutics and vaccines.
• For example, TriLink has developed CleanCap technology, which provides GMP-grade CleanCap reagents. These reagents enable the efficient development of 5' Cap1 mRNA with 95% efficiency, offering a quick and easy method for mRNA production.
• The continuous advancements in capping technologies are anticipated to further propel segment growth and drive the overall market.

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