What is Pazopanib?

Pazopanib is a targeted therapy used primarily to treat certain types of cancer, including:

Renal cell carcinoma (RCC): It is usually prescribed for advanced kidney cancer.

Soft tissue sarcoma: Pazopanib is also approved for the treatment of certain types of soft tissue sarcoma that are not suitable for surgery.

Mechanism of action
Pazopanib is a multi-kinase inhibitor that targets several key pathways involved in tumor growth and angiogenesis (the formation of new blood vessels that supply the tumor). By inhibiting these pathways, it helps slow or stop the growth of cancer cells.

Administration
Form: Taken orally as a tablet.

Dosage: Usually prescribed once a day, with or without food.

Common side effects of Pazopanib?

Common side effects of pazopanib include:

Fatigue: Many patients report feeling tired or weak.

Diarrhea: Frequent loose stools are experienced.

Nausea: Some individuals may feel nauseated or vomit.

Loss of appetite: A loss of appetite may lead to weight loss.

Hypertension: Blood pressure may increase.

Rash: Skin reactions, including rash and dry skin.

Hand-foot skin reaction: This includes redness, swelling, and pain on the palms and soles of the feet.

Abdominal pain: Some patients may experience discomfort in the abdominal area.

If you experience any side effects, especially if they are severe or persistent, it is important to talk to your healthcare provider for proper management.

Serious side effects of pazopanib?

Serious side effects of pazopanib may include:

Liver dysfunction: Elevated liver enzymes may indicate liver damage, which may require monitoring and discontinuation of the medication.

Gastrointestinal bleeding: There is a risk of serious bleeding in the gastrointestinal tract, which can be life-threatening.

Cardiovascular problems: Pazopanib can cause cardiovascular problems, including high blood pressure and, in rare cases, heart attack or arrhythmias.

Severe allergic reactions: Although rare, some patients may have severe allergic reactions, including anaphylaxis.

Pulmonary toxicity: Rarely, patients may develop lung problems, such as interstitial lung disease.

Thromboembolic events: There is an increased risk of blood clots, which can lead to complications such as deep vein thrombosis or pulmonary embolism.

Serious hand-foot skin reaction: Although common, severe cases may cause considerable discomfort and require dose adjustments.

Regular monitoring and prompt reporting of any severe or unusual symptoms to a healthcare provider are essential to effectively manage these risks and Pazopanib Cost Philippines.