Liver Disease Caused by Anesthetics, Chemicals, Toxins, and Herbal and Dietary Supplements
CCl4 is a classic example of a zone 3 hepatotoxin that causes necrosis leading to hepatic failure (seeTable 89.4). Injury is mediated by its metabolism to a toxic trichloromethyl radical catalyzed by CYP2E1.18,64 Alcohol potentiates the injury through induction of this cytochrome.2 Most cases have been...
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