Latest Developments in Traumatic Brain Injury Therapeutics Pathophysiology of TBI and Ongoing Challenges Traumatic brain injury (TBI) occurs due to a direct impact or blast waves resulting in damage to brain cells and tissues. The primary injury is caused at the moment of impact and involves bruising, tearing and shearing of soft tissues. This is followed by a complex series of secondary injury cascades including glutamate excitotoxicity, ionic shifts,...
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