The choice of Pulmonary Arterial Hypertension Drugs for the treatment of PAH depends on several factors, including the severity of the disease, the patient's age and gender, and the presence of other medical conditions. Treatment typically involves a combination of drugs from different classes. Combination therapy has been shown to be more effective than monotherapy in improving symptoms and slowing.

Oxygen therapy, diuretics, digoxin, exercise, and anticoagulation are all examples of supportive therapy. Each of these therapies should be initiated on a patient-by-patient basis in the appropriate clinical setting. Pulmonary Arterial Hypertension Drugs treatments are not particular to PAH and are often used in all WHO pulmonary hypertension classes.  Advanced vasodilatory therapy, on the other hand, are mostly reserved for patients with PAH. Guidelines advise against utilising these sophisticated therapies in cases of pulmonary hypertension caused by left-sided cardiac disease or pulmonary illness, and they should only be used in specialised centres and by physicians with extensive experience treating PAH.

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