Exposure to dichloromethane can lead to toxicity caused by its...

Exposure to dichloromethane can lead to toxicity caused by its metabolite carbon monoxide

Posted 2023-11-22 09:45:37

Dichloromethane, also known as dichloromethane, is an organic solvent used in a variety of industrial applications. Exposure to DCM can lead to direct effects of DCM or toxicity caused by its metabolite carbon monoxide.

A 27-year-old man, a worker at a paint stripping plant, fell down a well and immediately lost consciousness. He was sedated, intubated and taken to the hospital.

Hospital blood gas showed severe metabolic acidosis and elevated carbon monoxide levels - FCOHb 23.9%. Chest radiographs showed bilateral uneven pulmonary infiltration.

Analysis of the chemicals present in the well revealed concentrations of methylene chloride of >50%. Hyperbaric oxygen therapy was administered and the patient was discharged from the hospital after a total of 10 days with no sequelae.

Initial clinical suspicion and rapid confirmation of dichloromethane poisoning are critical because the rate of action and the regime of appropriate treatment can determine the patient's prognosis.

Methylene chloride monoxide intoxicating drug

Dichloromethane (DCM), also known as dichloromethane (dichloromethane sds), is an organic solvent used in a variety of industrial applications, such as degreasing agents, extraction media, paint remover, or paint remover, and is a very volatile substance (Figure 1). At room temperature, it is a highly volatile colorless liquid with an odor similar to chloroform. The limit for industrial use in the air has been set at 50 ppm (174 mg/m3).

Exposure to DCM can lead to direct effects of DCM or toxicity caused by its metabolite carbon monoxide. Inhalation is the most important route of exposure, but poisoning is also possible through the skin and after ingestion. Most of the effects of 3 DCM are observed after acute exposure and are caused by its direct central nervous system inhibitory effects, conversion to carbon monoxide in vivo, or oxidation to phosgene in an open flame.