The Rise Of Biosurgery: Innovating Surgical Techniques Through Biology
History and Development of Biosurgery
The field of biosurgery emerged in the 1980s as scientists began exploring ways to augment traditional surgical techniques with components derived from living organisms. Some of the earliest investigations involved using growth factors isolated from platelets to accelerate wound healing. By the 1990s, biosurgery had expanded to incorporate biologics like synthetic skin replacements, bone grafts, and adhesion barriers between tissues. The goal was to harness the body's innate healing responses and replicating natural biological structures using engineered alternatives.
Biologics For Wound Management
One major focus of Biosurgery has been developing advanced wound care solutions. Fibrin glues made from purified blood proteins provide a biological adhesive that can be sprayed over surgical incisions or lacerations to mimic the body's natural clotting process. Additionally, a variety of growth factor concentrates and cytokine mixtures extracted from platelets, blood plasma, or genetically engineered cell cultures contain molecules that recruit stem cells and immune cells to wound sites. When applied topically or through catheters, these biologic formulations can significantly accelerate re-epithelialization and angiogenesis. Some wound dressings are infused with keratinocytes, fibroblasts, or mesenchymal stem cells grown on collagen scaffolds, which secrete healing signals while physically filling defects. Customized skin substitutes engineered at a cellular level offer an attractive alternative to skin grafting.
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