Sevoflurane An Inhalational Anesthetic Agent with Advantageous Properties
Introduction to Sevorane
Sevorane is a highly fluorinated methyl isopropyl ether that has been widely used as an inhalational anesthetic agent since the 1990s. With low pungency and nonirritating properties, Sevorane provides rapid induction and emergence from anesthesia.
Chemical and Physical Properties
Chemically, Sevorane is classified as a haloether. Its molecular formula is C4H3F7O and molar mass is 200.05 g/mol. As an ether, Sevorane is highly volatile and has a low boiling point of 58.5°C. Sevoflurane An Inhalational Anesthetic Agent.This allows it to rapidly vaporize and mix well with carrier gases like nitrous oxide and oxygen. Sevorane is nonflammable due to its chemical structure containing multiple fluorine substitutions.
Mechanism of Action
Sevorane produces anesthesia by potentiating the inhibitory effects of gamma-aminobutyric acid (GABA) on neurons in the central nervous system. Like other inhaled anesthetics, it increases the frequency of chloride channel opening when GABA binds to its receptor on neurons. This enhanced chloride conductance hyperpolarizes the neuronal cell membrane and diminishes its excitability. Sevorane also interacts with glutamate and other receptor systems to mediate its anesthetic effects.
Sevoflurane has become one of the most preferred volatile agents for general anesthesia worldwide due to its favorable properties involving non-pungency, rapid induction/emergence, hemodynamic stability, and reduced airway irritancy. With appropriate usage adhering to manufacturer guidelines by trained professionals, it delivers safe and effective surgical anesthesia, particularly well-suited for outpatient surgeries wherein swift recovery is imperative. Future research continues exploring new avenues to improve patient safety and therapeutic profiles of inhalational anesthetics like Sevorane.
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