Herpes Simplex Virus (Hsv) Vaccines: Progress On Simplex Virus (Hsv) Vaccines Industry
What are Herpes Simplex Virus (Hsv) Vaccines?
Herpes simplex viruses (HSV) are members of the herpesviridae family. There are two types of HSV - HSV-1 which primarily causes oral herpes (cold sores) and HSV-2 which primarily causes genital herpes. Both viruses are highly contagious and can also cause infections in other parts of the body. HSV establishes a life-long infection in the host after initial exposure, residing in the sensory ganglia between recurrent outbreaks.
Current vaccines and Herpes Simplex Virus (Hsv) Vaccines
Researchers have been working on developing Herpes Simplex Virus (Hsv) Vaccines vaccines for decades due to the large disease burden caused by these viruses worldwide. However, producing an effective vaccine against HSV has proven challenging for several reasons:
- HSV establishes latent infections which allows the virus to evade immune detection and response between recurrent outbreaks. Vaccines need to promote immune responses that can control latent viral reactivation as well as infection of new hosts.
- HSV has evolved mechanisms to suppress immune activation by the host. Effective vaccines need to overcome these immune evasion strategies of the virus.
- Both HSV-1 and HSV-2 infect the same anatomical sites in humans. An ideal vaccine would need to protect against infection and disease caused by both viruses.
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