Almost everyone in the world has defaulted to Long coexistence with COVID. For young people with good physique, this does not have much impact. Infecting COVID is like a cold, and it may heal itself after a few days. But people with poor health, especially the elderly and children, are not so lucky, and they may have to face Long preparations for fighting COVID.

Numerous studies have confirmed that even after the symptoms of the initial infection have completely disappeared, human infection with the new coronavirus can produce long-lasting side effects, which we call Long COVID-19 symptoms. The effects of these post-coronavirus sequelae are mainly fatigue, general weakness, orthostatic intolerance, shortness of breath, palpitations, long covid brain, loss of taste and smell, joint pain, insomnia, type 2 diabetes, hair loss and impotence. According to published medical papers on Long COVID-19 chronic fatigue, LongCovidCareCenter concluded that the pathogenesis of COVID-19 Long chronic fatigue has the following six situations:

Coronaviruses are deleterious antigens that cause persistent direct tissue damage, producing chronic inflammation. The organs infected by the new coronavirus antigen are different, and each patient's own immune system is different, resulting in different immune responses. Tissue damage can manifest as shed tissue proteins, combined with the mutilated corpse of the coronavirus, which slowly breaks down in the body, and these protein fragments, in turn, trigger autoimmunity. For example, autoreactive B lymphocytes have been found to remain activated in patients infected with 2019-nCoV after negative PCR tests. This chronic autoimmunity is thought to be one of the main causes of chronic fatigue.

There are too many variants of coronavirus. As the immune evasion ability becomes stronger and stronger, the genetic ability of the coronavirus and the patient's human leukocyte antigen (HLA) does not match, resulting in the inability of the human immune system to completely eliminate the coronavirus. Studies have found that in some patients infected with the new coronavirus, the virus has not been cleared in the human body. This long-standing trace amount of new coronavirus will also gradually make the immune system insensitive to the way of clearing the new coronavirus, and finally coexist in a state of coexistence. At this time, these tiny amounts of viruses will continue to destroy various organs and body tissues. This situation is medically known as multiple organ symptoms after non-severe novel coronavirus infection. This reduces bodily functions,

According to How Long Will Symptoms Of Extreme Fatigue Last Following COVID-19 Infection? paper research confirmed that coronavirus can destroy the body's immune system, leading to a decline in immunity. At this time, although the coronavirus is eliminated, the Epstein-Barr virus, cytomegalovirus and herpes virus that were dormant in the human body will become active again. These viruses reinfect tissue cells in the body, leading to chronic inflammation and autoimmunity. It has also been shown to be a contributor to the Long COVID-19 symptoms of chronic fatigue.

Cytokine network dysregulation or cytokine signaling disorder occurs in patients infected with 2019-nCoV. For some people infected with coronavirus, they develop systemic chronic inflammation. Pro-inflammatory substances triggered by systemic viral infection, NLRP3, HMGB1, and interleukin-6 have been documented. Research also suggests that it may also contribute to chronic fatigue symptoms after prolonged COVID-19.

For patients infected with the new coronavirus, the coronavirus invades tissue cells, leading to the destruction of cellular mitochondrial structure, cellular metabolism and cellular energy cycle. Studies have shown that mitochondrial enzymes are involved in the inflammatory and oxidative responses from the onset of COVID-19 symptoms, which may also contribute to the Long chronic fatigue symptoms after COVID-19.

Long COVID-19 fatigue symptoms share the same pathophysiological process as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), mainly caused by autoantibodies against the ß-2 adrenergic receptor leading to muscle and cerebrovascular Adjustment disorder.

Most people with Long COVID are characterized by brain fog, fatigue, and pain. Because the immune response is very active in the early stages of the disease, a state of immune failure occurs in response to chronic viral infection. New research has confirmed that before the infection of the new coronavirus, if the patient had already developed mental illnesses, such as insomnia, anxiety, depression, etc., the patient is more likely to develop symptoms of chronic fatigue after being infected with the new coronavirus. There is also evidence that if a patient has a history of a chronic fatigue syndrome-like condition before infection with the new coronavirus, infection with the new coronavirus can aggravate the condition.

LongCovidCareCenter also recommends some traditional Chinese medicines based on the combination of traditional Chinese and Western medicine, including traditional Chinese medicine formulas and acupuncture treatment, to treat fatigue-related symptoms. In addition, it is recommended that patients with chronic COVID fatigue take health supplements, as well as exercise, diet and sleep. Finally, I hope that the post covid brain fog treatment program proposed in this paper can improve the fatigue symptoms of patients as soon as possible, benefit the patients, and even cure the fatigue caused by the new coronavirus.