Gene Synthesis: Unlocking the Secrets of DNA
DNA printing is a technique in which a DNA sequence of interest is constructed inside a machine through an automated process. The process involves selection of short DNA fragments called oligonucleotides, typically around 100 nucleotides in length, that correspond to the desired gene sequence. These oligonucleotides are then combined through enzymatic reactions to assemble the full-length gene. This allows scientists to create genes that either exist in nature or are artificially designed in the lab.
Some Key Applications of DNA printing
Bioengineering and Synthetic Biology
Gene Synthesis printing enables the construction of novel organisms through bioengineering of existing microbes, plants and animals. Synthetic biologists can build biological systems and circuits from scratch by assembling genes to program living cells. This has potential applications ranging from biofuels and biomaterials to bioremediation and microbial therapeutics. For example, scientists have synthesised the complete genome of yeast and bovine herpesvirus to better understand their biology.
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