Cell-Based Assay: An Effective Technique for Drug Discovery and Development
Cell-based Assay have become a standard technique in drug discovery and development processes. By using live human cells, cell-based Assay allow scientists to study the effects of potential drug candidates in a biologically relevant environment before moving to animal and human testing. This provides important insights into how a candidate may affect the body and helps optimize properties such as efficacy and safety.
Types of Cell-Based Assay
There are several main types of cell-based Assay used in drug development:
Cytotoxicity Assay
Cytotoxicity Assay measure the ability of a substance to cause cell death or inhibit cell growth. Cell-Based Assay are commonly used early in the drug discovery process to screen for toxic effects. Assay determine cytotoxicity by measuring membrane integrity, metabolic activity, protein content and other indicators of live vs. dead cells. This helps identify non-toxic concentration ranges for further study.
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