| N-glycan Sites Occupation Analysis | N-glycan is used as a standard for QC analysis of biopharmaceuticals. N-glycan analysis is an important biochemical technology for the research and development of biopharmaceuticals and the comparative research projects of biosimilars and innovative drugs. The technical method can be used to determine the characterization and analysis information of N-glycan sequence information of biopharmaceutical proteins or other biological agents, the connection mode of monosaccharide residues and the number of glycan isomers. |
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N-glycan Sites Occupation Analysis
| structure of siliac acid | Sialic acids are negatively charged monosaccharides, what are found on the non-reducing termini of glycans. The key role in product stability and efficacy, thus, sialic acids are often defined in glycoprotein therapeutic products. There exist two most common sialic acids in biopharmaceuticals, the one is N-acetyl-neuraminic acid (Neu5Ac) and the other one is N-glycolyl-neuraminic acid (Neu5Gc). The sialic acid mentioned above are both important to the firmness and 3D conformation of glycoproteins, they are involved in many biological interactions. |
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