Global Hereditary Orotic Aciduria: An Understanding of its Genetic...

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2024-05-08 12:15:52 -

Global Hereditary Orotic Aciduria: An Understanding of its Genetic Basis, Presentation, and Management

Orotic aciduria is a rare autosomal recessive inborn error of pyrimidine metabolism resulting from mutations in the UMPS gene. This gene codes for the enzyme orotate phosphoribosyltransferase (OPRT), which plays a key role in the catabolism of uridine monophosphate (UMP). Deficiency of this enzyme leads to the accumulation and excessive excretion of orotic acid in the urine. If left untreated,...

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