What is it?Global spastic paraplegia 50 (SPG50) is a rare, progressive neurological disorder that causes weakness and stiffness (spasticity) in the lower limbs. It belongs to a family of genetic conditions called hereditary spastic paraplegias (HSPs), which are characterized by stiff, rigid muscles in the legs along with weakness. SPG50 is caused by mutations in the MAP1B gene, which provides...
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