Patient derived xenograft (PDX) models are an innovative tool to use human cancer tissue to establish a mouse model and study cancer biology and drug testing. PDX models help retain the genetic and molecular characteristics of the original patient's tumor and demonstrate clinical relevance by recapitulating responses to therapy similarly to patients in clinical trials. They provide a renewable...
One of the significant advantages of PDX models in precision medicine is their ability to closely mimic the patient’s tumor in vivo. Unlike traditional cell lines, which often lose their original characteristics over time, PDX models maintain the histological architecture, genetic heterogeneity, and molecular features of the primary tumor. This fidelity allows researchers to observe how a...
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