Leaking 188 and CNS Disorders Research suggests that leak 188 may be useful in treating CNS disorders. This is based on the fact that it can prevent membrane toxicity caused by misfolded SOD1.
P188 also protects brain endothelial cells against mechanical trauma. In an in vitro model, it restored BBB permeability and mitigated disorganized tight junctions. It also regulated AQP4 expression and suppressed apoptosis....
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