Pan-Cancer Analysis Uncovers Structural Variants as Vital Contributors to Tumor Neoantigens
Within the tumor genome, somatic mutations hold the ability to yield altered proteins that trigger immune responses against tumors. These mutated proteins fragment into peptides and are showcased on major histocompatibility complex (MHC) molecules. These distinct peptides, coined as "neoantigens," play a pivotal role in anti-tumor immune activity and have emerged as promising targets for...
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