ER Stress and the Unfolded Protein Response
or decades, biological psychiatry focused on the macro-mechanics of the synaptic cleft. If an individual presented with treatment-resistant depression (TRD), severe cognitive slowing, or structural executive dysfunction, the medical narrative blamed a shortage of monoamine neurotransmitters or localized receptor downregulation.
As we progress through 2026, the clinical paradigm has shifted from...
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