Land spreading of dairy soiled water (DSW) may result in pollution of ground and surface waters. Treatment of DSW through sludge-supernatant separation using chemical coagulants is a potential option to reduce the negative environmental impacts of DSW. The aims of this study were to (1) assess the effectiveness of three chemical coagulants - poly-aluminium chloride (PACl), ferric chloride (FeCl3) and alum - in improving effluent quality, and (2) assess the properties of the sludge that is generated as by-product from the process for its suitability for land application. Taking into consideration optimum doses to minimize pollutants (turbidity, chemical oxygen demand (COD), total phosphorus (TP), total nitrogen (TN), and E. coli), optimum mixing times and cost, FeCl3 was the best performing coagulant. Generated sludges had higher nutrient content and fewer E. coli than raw DSW, and did not display any evidence of phytotoxicity to the growth of Lolium perenne L. using germination tests. The study discussed the results in a sustainable farm management context, and suggested that the effluent (supernatant) from the treatments may be recycled to wash farm yards, saving water. In parallel, the sludge portion can be applied to amend soil properties with no adverse impacts on the grass growth, providing an agronomic value as an organic fertilizer, and reducing the risk of nutrient losses. This management approach could minimize the overall net cost compared to land application of raw DSW. China implemented the National Wetland Conservation Program (NWCP) from 2002 to protect and rehabilitate wetlands. Under the background of sustainable development, assessment on the effectiveness of the NWCP is important to ecosystem management, especially in the Sanjiang Plain, the largest marsh distribution area and hotspot area with wetland loss. To achieve this aim, this study examined the changes in land cover and ecosystem services (ESs) from 1990 to 2000 and from 2000 to 2015 in the Sanjiang Plain as well as the nine national nature reserves for wetlands (NNRWs) by means of Landsat series images and the InVEST model. Results reveal that the NWCP played critical roles in reducing wetland loss and improving regional ESs. The shrinkage rate of wetlands in the Sanjiang Plain has been decreased remarkably, with a declined rate of wetland loss from 750 km2 yr-1 to 189 km2 yr-1. The reduction rate of habitat area in good suitable grade and ecosystem carbon stock declined notably during the period 2000-2015 compared to the period 1990-2000. The amount of water retention increased by 5.4%, while the grain production capacity was enhanced by nine times from 1990 to 2015. Specifically, since 2000, the reduction rate of wetland area in NNRWs (33 km2 yr-1) was obviously lower than that in the entire Sanjiang Plain, whilst various ESs in NNRWs were better than that in the whole Sanjiang Plain. This study is expected to provide an example for evaluating the effectiveness of the NWCP at other regions and support regional wetland conservation management. BACKGROUND The COVID-19 pandemic has forced a reorganization of healthcare systems and an exceptional saturation of their resources. https://www.selleckchem.com/products/cynarin.html In this context, it is vital to ensure acute stroke care and optimize the care processes of the stroke code to reduce the risk of contagion and rationalize the use of hospital resources. To do this, the Ictus Madrid Multidisciplinary Group proposes a series of recommendations. METHODS Non-systematic bibliographic review of the available publications with the terms «stroke» and «COVID-19» or «coronavirus» or «SARS-CoV-2», as well as other already known for the authors. We provide a document of recommendations as a result of the consensus of the Ictus Madrid Multidisciplinary Group and its Neurology Committee. RESULTS Our recommendations are structured on five lines (1)coordinate to guarantee the access to hospital care for stroke patients, (2)recognize potentially COVID-19 infected stroke patients, (3)organize to ensure the protection of healthcare professionals from COVID-19 infections, (4)neuroimaging and other procedures potentially associated to risks for COVID-19 infection should be reduced and secured to avoid contagion, and (5)at home as soon as possible and supported follow-up to optimize hospital occupancy. The procedure is shown summarized under the acronym CORONA (COordinate, Recognize, Organize, Neuroimaging, At home). CONCLUSIONS These recommendations can support the organization of healthcare services for acute stroke care and the optimization of their resources, guaranteeing the protection of healthcare professionals. INTRODUCTION The COVID-19 pandemic will give rise to long-term changes in neurological care, which are not easily predictable. MATERIAL AND METHODS A key informant survey was used to enquire about the changes expected in the specialty over the next 5 years. The survey was completed by heads of neurology departments with broad knowledge of the situation, having been active during the pandemic. RESULTS Despite a low level of consensus between participants, there was strong (85%) and moderate consensus (70%) about certain subjects, mainly the increase in precautions to be taken, the use of telemedicine and teleconsultations, the reduction of care provided in in-person consultations to avoid the presence of large numbers of people in waiting rooms, the development of remote training solutions, and the changes in monitoring visits during clinical trials. There was consensus that there would be no changes to the indication of complementary testing or neurological examination. CONCLUSION The key informant survey identified the foreseeable changes in neurological care after the pandemic. INTRODUCTION SARS-CoV-2 was first detected in December 2019 in the Chinese city of Wuhan and has since spread across the world. At present, the virus has infected over 1.7 million people and caused over 100 000 deaths worldwide. Research is currently focused on understanding the acute infection and developing effective treatment strategies. In view of the magnitude of the epidemic, we conducted a speculative review of possible medium- and long-term neurological consequences of SARS-CoV-2 infection, with particular emphasis on neurodegenerative and neuropsychiatric diseases of neuroinflammatory origin, based on the available evidence on neurological symptoms of acute SARS-CoV-2 infection. DEVELOPMENT We systematically reviewed the available evidence about the pathogenic mechanisms of SARS-CoV-2 infection, the immediate and lasting effects of the cytokine storm on the central nervous system, and the consequences of neuroinflammation for the central nervous system. CONCLUSIONS SARS-CoV-2 is a neuroinvasive virus capable of triggering a cytokine storm, with persistent effects in specific populations.