After ingestion or inhalation, epichlorohydrin is rapidly absorbed into the body through the skin. Epichlorohydrin itself is a reactive epoxide that is metabolized by conjugation to glutathione and hydration by epoxide hydrolases. The same hemoglobin adducts have been detected in epichlorohydrin humans and rats. Epichlorohydrin is widely distributed throughout the body. In rodents, the highest...
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