Physicochemical properties of the free and complexed ligand differ substantially.A library of 14 heterobis(carbene) complexes of the general formula [Au(iPr2-bimy)(ADC)]BF4 (7-20) containing the N-heterocyclic carbene reporter iPr2-bimy and various protic acyclic diaminocarbenes (ADCs) have been prepared to estimate their stereoelectronic properties by 13C NMR spectroscopy and percentage buried volume (%Vbur) determinations. Their preparation was achieved by nucleophilic attack of five secondary amines on six mixed NHC/isocyanide complexes of the type [Au(iPr2-bimy)(CN-R)]BF4 (1-6). Analyses of the iPr2-bimy carbene signals reveal that protic ADCs are stronger donors than classical and expanded-ring NHCs. On the other hand, they are weaker donating compared to NHCs with reduced-heteroatom stabilization. Moreover, stereoelectronic fine-tuning of these ligands is possible by a diverse range of substituents originating from the employed isocyanides and amines.Plasma-free metanephrines and catecholamines are essential markers in the biochemical diagnosis and follow-up of neuroendocrine tumors and inborn errors of metabolism. However, their low circulating concentrations (in the nanomolar range) and poor fragmentation characteristics hinder facile simultaneous quantification by liquid chromatography and tandem mass spectrometry (LC-MS/MS). Here, we present a sensitive and simple matrix derivatization procedure using propionic anhydride that enables simultaneous quantification of unconjugated l-DOPA, catecholamines, and metanephrines in plasma by LC-MS/MS. Dilution of propionic anhydride 14 (v/v) in acetonitrile in combination with 50 μL of plasma resulted in the highest mass spectrometric response. In plasma, derivatization resulted in stable derivatives and increased sensitivity by a factor of 4-30 compared with a previous LC-MS/MS method for measuring plasma metanephrines in our laboratory. Furthermore, propionylation increased specificity, especially for 3-methoxytyramine, by preventing interference from antihypertensive medication (β-blockers). The method was validated according to international guidelines and correlated with a hydrophilic interaction LC-MS/MS method for measuring plasma metanephrines (R2 > 0.99) and high-performance liquid chromatography with an electrochemical detection method for measuring plasma catecholamines (R2 > 0.85). Reference intervals for l-DOPA, catecholamines, and metanephrines in n = 115 healthy individuals were established. Our work shows that analytes in the subnanomolar range in plasma can be derivatized in situ without any preceding sample extraction. The developed method shows improved sensitivity and selectivity over existing methods and enables simultaneous quantification of several classes of amines.The layered oxide Na2Zn2TeO6 is a fast Na+ ion conductor and a suitable candidate for application as a solid-state electrolyte. We present a detailed study on how synthesis temperature and Na-content affect the crystal structure and thus the Na+ ion conductivity of Na2Zn2TeO6. Furthermore, we report for the first time an O'3-type phase for Na2Zn2TeO6. At a synthesis temperature of 900 °C, we obtain a pure P2-type phase, providing peak performance in Na+ ion conductivity. Synthesis temperatures lower than 900 °C produce a series of mixed P2 and O'3-type phases. The O'3 structure can only be obtained as a pure phase by substituting Li on the Zn-sites to increase the Na-content. Thorough analysis of synchrotron data combined with computational modeling indicates that Li enters the Zn sites and, consequently, the amount of Na in the structure increases to balance the charge according to the formula Na2+xZn2-xLixTeO6 (x = 0.2-0.5). https://www.selleckchem.com/products/ugt8-in-1.html Impedance spectroscopy and computational modeling confirm that reducing the amount of the O'3-type phase enhances the Na+ ion mobility.Today's great challenges of energy and informational technologies are addressed with a singular compound, Li- and Na-doped few-layer graphene. All that is impossible for graphite (homogeneous and high-level Na doping) and unstable for single-layer graphene works very well for this structure. The transformation of the Raman G line to a Fano line shape and the emergence of strong, metallic-like electron spin resonance (ESR) modes attest the high level of graphene doping in liquid ammonia for both kinds of alkali atoms. The spin-relaxation time in our materials, deduced from the ESR line width, is 6-8 ns, which is comparable to the longest values found in spin-transport experiments on ultrahigh-mobility graphene flakes. This could qualify our material as a promising candidate in spintronics devices. On the other hand, the successful sodium doping, this being a highly abundant metal, could be an encouraging alternative to lithium batteries.The ability to allow microliquid to penetrate in one direction but block in the opposite direction plays an irreplaceable role in intelligent liquid management. Despite much progress toward facilitating directional transport by multilayer porous membranes with opposite wettability, it remains difficult to achieve a highly multifunctional flexible membrane for highly efficient unidirectional liquid transport in different situations. Herein, a superhydrophilic-hydrophilic self-supported monolayered porous poly(ether sulfone) (PES) membrane with special nano- and micropores at opposite surfaces is demonstrated, which can be used for unidirectional liquid transport. The results reveal that the competition of liquid spreading and permeation is critical to achieve directional liquid transport. The porous PES membrane, transformed with 70 vol % of ethanol in water (E/W-PES-70%), exhibits continuous unidirectional liquid penetration and antigravity unidirectional ascendant in a large range of pH values and can be used as "liquid diode" for moisture wicking. Moreover, the PES membrane can be prepared in a large area with excellent flexibility at room and liquid nitrogen temperature, indicating great promise in harsh environments. This work will provide an avenue for designing porous materials and smart dehumidification materials, which have promising applications in biomedical materials, advanced functional textiles, engineered desiccant materials, etc.