The implementation of acupuncture and moxibustion refers to acupuncture or moxa burning at the selected sites on the surface of the body, and such sites have different natures and belong to different categories. The current theoretical system of acupuncture and moxibustion only contains the category of "acupoints" and their classification and does not cover all related concepts, which has an adverse effect on the inheritance, application, and research of acupuncture and moxibustion. Based on a deeper analysis of related theories, this article analyzes the nature and features of different sites for acupuncture and moxibustion on the surface of the body and proposes a frame for the classification of acupuncture treatment sites, hoping to constantly improve the theoretical system of acupuncture and moxibustion and give full play to its role. To investigate the clinical effect and safety of moxibustion therapy based on Sancai theory for reinforcing intelligence in the early intervention of mild cognitive impairment (MCI). A total of 210 patients with MCI were divided into moxibustion group and medication group using a random number table, with 105 patients in each group. The patients in the moxibustion group were given moxibustion at Baihui (GV20), Shenque (CV8), and Yongquan (KI1) once every other day, 20 minutes each time, for a total of 8 weeks, and those in the medication group were given oral Nimodipine 30 mg once a day for 8 weeks. Mini-Mental State Examination (MMSE) score, score of meaningless graphics recognition of Clinical Memory Scale (CMS), and event-related potential P300 latency were evaluated before treatment, after 8 weeks of treatment, and at 12 weeks after treatment, and the safety of treatment was analyzed for both groups. Both groups had significant increases in MMSE score and the score of meaningless graphics recognition of CMS and a significant reduction in P300 latency after treatment and during follow-up ( <0.01, <0.05). Compared with the medication group, the moxibustion group had a significant increase in MMSE score and a significant reduction in P300 latency after treatment ( <0.05). Moxibustion therapy based on Sancai theory for reinforcing intelligence can improve cognitive impairment in patients with MCI and is thus an effective intervention method for improving the cognitive function of patients with MCI. Moxibustion therapy based on Sancai theory for reinforcing intelligence can improve cognitive impairment in patients with MCI and is thus an effective intervention method for improving the cognitive function of patients with MCI. To observe the clinical efficacy and safety of electroacupuncture (EA) at Neimadian-point for cancer pain. A total of 140 cancer patients with pain were randomly divided into EA and control groups, with 70 cases in each group. The patients of the EA group received EA at Neimadian-point plus analgesia pump (all prepared with normal saline). The patients of the control group were treated by Sufentanil patient-controlled intravenous analgesia plus sham EA (without stimulation). The treatment was conducted once daily for two days at 8 o'clock every morning. Respectively, in 1 h before treatment (T0), 1 h (T1), 8 h (T2), 24 h (T3) after treatment of the first day, 1 h (T4), 8 h (T5), 24 h (T6) after treatment of the second day, the visual analogue scale (VAS) score of pain, and the plasma levels of norepinephrine, 5-HT, leucine enkephalin, β-endorphin and dynorphin A1-13 were tested. The security level (1-4 grade) was assessed during the treatment. Compared with their own pre-treatment, in T1 to T6, the VAS scores, and the contents of plasma norepinephrine and 5-HT obviously decreased in both groups （ <0.05）, and the contents of leucine enkephalin, β-endorphin and dynorphin A1-13 all increased ( <0.05) in the EA group. The analgesia effects were significantly higher in the EA group than in the control group in T1, T2, T4 and T5 ( <0.05, <0.01). The therapeutic effect of EA at Neimadian-point was significantly superior to that of the Sufentanil in down-regulating plasma norepinephrine and 5-HT levels, and in up-regulating leucine enkephalin, β-endorphin and dynorphin A1-13 levels ( <0.05, <0.01). EA at Neimadian-point can effectively relieve the pain of cancer patients and improve their quality of daily life. EA at Neimadian-point can effectively relieve the pain of cancer patients and improve their quality of daily life. To explore the clinical efficacy and possible efficacy mechanisms of Governor Vessel moxibustion therapy in patients with carotid atherosclerosis (CAS). A total of 100 patients with CAS were randomly divided into Governor Vessel moxibustion therapy group ( =51) and control group ( =49). https://www.selleckchem.com/products/GDC-0980-RG7422.html The patients in the Governor Vessel moxibustion therapy group were treated by herbal cake-partitioned moxibustion ［applied on Governor Vessel from Dazhui (GV14) to Yaoshu (GV2)］, once a week, for 8 weeks. Patients in the control group received oral administration of atorvastatin calcium tablets (10 mg) once daily for 8 weeks. Before and after treatment, the patients' constitution quantized score, body mass index (BMI), carotid intima-media thickness (IMT) and laboratory indicators ［including total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), homocysteine (Hcy), fibrinogen (Fbg), and hypersensitive C-reactive protein (hs-CRP)］ were observed, and their clinical efficacy was evaluated. After the treion therapy can effectively treat CAS, and its mechanism may be related to the improvement of risk factors such as high level of TC, TG, LDL, Fbg, and hs-CRP. The Governor Vessel moxibustion therapy can effectively treat CAS, and its mechanism may be related to the improvement of risk factors such as high level of TC, TG, LDL, Fbg, and hs-CRP.According to the operative characteristics, the stimulated site and the curative effect-emerged site of bloodletting therapy, its clinical characteristics may be divided into three categories a) local stimulation induced focus-local effect, b) local stimulation induced effect of the distal target organ (point-to-point distal effect), and c) special point stimulation induced broader effect of the whole body. Accordingly, the underlying mechanisms of clinical outcomes mainly involve the improvement of the local microcirculation and secondary changes of inflammatory substances for the first category (local focus). The point-to-point distal effect might mainly involve the innervation of nerve segments, while the broad effect of specific acupoint stimulation might involve multiple levels of the neuro-endocrine-immune system. The future research on the mechanisms of bloodletting should starts from its specific effects and the type of disease, which should not be generalized.