BACKGROUND Lower-grade gliomas (LGG) with isocitrate dehydrogenase (IDH1/2) mutations have long survival times making evaluation of treatment efficacy difficult. We investigated the volumetric growth rate of IDH mutant gliomas before and after treatment with established glioma therapies to determine whether a significant change in growth rate could be documented and perhaps be used in the future to evaluate treatment response to investigational agents in LGG trials. METHODS In this multicenter retrospective study, 230 adult patients with IDH1/2 mutated lower-grade gliomas (WHO grade II or III) undergoing surgery, radiation or chemotherapy for progressive non-enhancing tumor were identified.  Subjects were required to have 3 MRI scans containing T2/FLAIR imaging spanning a minimum of 6 months prior to treatment. A mixed-effect model was used to estimate tumor growth prior to treatment. A subset of 95 patients who received chemotherapy, radiotherapy, or chemoradiotherapy and had 2 post-treatment imaging time poUniversity Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.INTRODUCTION Malnutrition, suboptimal hydration, and inadequate body composition can have negative consequences on soldiers' performance and health. A recent consensus statement concerning "soldiers' physical performance" points to the scarcity of data in specific military populations. Therefore, the aim of the present study was to assess and compare dietary intake, hydration status, and body composition of three military groups during their specific military training. MATERIALS AND METHODS Eighty-five soldiers (ie, 21 in a qualification course to join the Special Forces [SF], 22 Infantrymen [Chasseurs Ardennais, CA], and 42 Recruits [REs]) participated in this 3- to 4-day study. Body mass was assessed before and after each study period. All soldiers self-reported their dietary intakes, from which energy and macronutrient intakes were calculated. In addition, their morning urine samples were collected daily to assess urine specific gravity (USG) as a measure of hydration status. Fat mass was estimated at the ditions. © Association of Military Surgeons of the United States 2020. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.The aquatic carnivorous plant Aldrovanda vesiculosa L. is critically endangered worldwide; its peculiar lifestyle raises many questions and poses problems both intriguing on their own and relevant to conservation. While establishing a culture system for its propagation and restoring its natural habitat in Hozoji pond in Saitama, Japan, we conducted ultrastructural observations to examine various aspects of Aldrovanda's way of life. Electron microscopic observation in combination with cryo-techniques produced novel information which could not be obtained by other methods. Some of the results are phosphorous is stored in petiole cells of turions during winter; mucilaginous guides are provided for pollen tubes in parietal placental ovaries; storage of potassium in the vicinity of the midrib of carnivorous leaves may contribute to the rapid closing of the carnivorous leaves; dynamic sequential changes of the ultrastructure of digestive glands is involved in synthesis and secretion of digestive enzymes including protease and acid phosphatase. These results should contribute significantly to our understanding of Aldrovanda and the detailed mechanisms of its life. © The Author(s) 2020. https://www.selleckchem.com/ Published by Oxford University Press on behalf of The Japanese Society of Microscopy. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.The environmental radioactivity levels of two typical uranium mines in the south of China were investigated and analysed. According to the characteristics of uranium mines, the relevant parameters, including the surface gamma ray dose rate, concentration of radon in the air and concentration of radionuclides in the soil and surface water, of two uranium mines were evaluated and analysed. The results show that residents in the mining area were exposed to average maximum annual effective doses of 1.69 and 1.58 mSv due to the inhalation of radon and its daughters, while the employees received 2.59 and 1.87 mSv, respectively. Residents in the mining area were exposed to average maximum annual effective doses of 0.77 and 0.69 mSv due to gamma ray, while the employees received 1.64 and 1.33 mSv, respectively. © The Author(s) 2020. Published by Oxford University Press. All rights reserved. For Permissions, please email journals.permissions@oup.com.STUDY OBJECTIVES Sleep is vital for brain development and healing after injury, placing children with sleep wake disturbances (SWD) after traumatic brain injury (TBI) at risk for worse outcomes. We conducted a systematic review to quantify SWD after pediatric TBI including prevalence, phenotypes, and risk factors. We also evaluated interventions for SWD and the association between SWD and other post-traumatic outcomes. METHODS Systematic searches were conducted in MEDLINE, PsychINFO, and reference lists for English language articles published from 1999-2019 evaluating sleep or fatigue in children hospitalized for mild complicated, moderate, or severe TBI. Two independent reviewers assessed eligibility, extracted data, and assessed risk of bias using the Newcastle-Ottowa Score for observational studies. RESULTS Among 966 articles identified in the search, 126 full text articles were reviewed, and 24 studies were included (11 prospective, 9 cross-sectional, and 4 case studies). Marked heterogeneity was found in study populations, measures defining SWD, and time from injury to evaluation. Studies showed at least 20% of children with TBI had trouble falling or staying asleep, fatigue, daytime sleepiness, and nightmares. SWD are negatively correlated with post-traumatic cognitive, behavioral, and quality of life outcomes. No comparative intervention studies were identified. Risk of bias was moderate-high for all studies often related to lack of validated or objective SWD measures and small sample size. Heterogeneity precluded meta-analyses. CONCLUSIONS SWD are important morbidities after pediatric TBI, though current data is limited. SWD have implications for TBI recovery, and may represent a modifiable target for improving outcomes after pediatric TBI. © Sleep Research Society 2020. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.