Anterior maxillary swellings are commonly encountered in the adolescents and adults and they represent lesions ranging from cysts to tumors which can be both benign as well as malignant. However the anterior maxillary swellings are a rare phenomenon in the infants and toddlers and they generally are indicative of an aggressive lesion. We hereby present a case of a rapidly growing infantile swelling which was histopathologically diagnosed as Peripheral Giant Cell Granuloma. Copyright © 2020 Journal of Oral and Maxillofacial Pathology.Pleomorphic Adenoma (PA), a benign neoplasm of glandular origin most commonly involves major salivary glands. It is rare in minor salivary glands such as hard palate, upper lip and buccal mucosa, frequently affecting middle aged females. PA comprises diverse histopathologic features of epithelial, myoepithelial and mesenchymal components. Aberrant histopathologic features in Pleomorhic Adenoma thus calls for judicious discrimination from alike entities which facilitates appropriate surgical management. Here we present a case report of PA in upper lip in a 25 year old female patient showing uncommon findings like clear cells, squamous metaplasia and cribriform pattern. Copyright © 2020 Journal of Oral and Maxillofacial Pathology.Central intraosseous adenoid cystic carcinoma (ACC) of the mandible, formerly known as cylindroma, is a rare neoplasm with only 47 cases reported in the literature. We present a case of central ACC involving the mandible of a 55-year-old male patient. Copyright © 2020 Journal of Oral and Maxillofacial Pathology.Central adenoid cystic carcinoma (ACC) of the mandible is a rare entity arising from minor salivary glands. Their clinical and radiographic features may be similar to any odontogenic/nonodontogenic pathology, thus making their precise diagnosis wearisome. ACC is well documented for its protracted clinical course, perineural invasion, multiple recurrence rates and its propensity for distant metastases. The aim of this study is to report a rare case of primary central ACC of the mandible with an unusual presentation in terms of location, however, demonstrating the classical features of ACC in histopathology and positivity in immunohistochemistry to S100, calponin and CD117. A thorough clinical, radiographic, CT evaluation and meticulous metastatic workup along with long-term follow-up is advised in such cases. Although central ACC is extremely rare, especially in the anterior mandible, it should be included in the differentials for lesions of the mandible. Copyright © 2020 Journal of Oral and Maxillofacial Pathology.Benign lymphoepithelial lesion (BLEL) is characterized by extensive lymphocytic infiltration of the major salivary glands and may be associated with Sjogren's syndrome or HIV infection. The involvement of the palatal minor salivary glands is extremely rare. We report an isolated case of BLEL affecting the palatal minor salivary glands, presenting as a palatal swelling in a 37-year-old female patient. Serological tests ruled out potential comorbid conditions. Cone-beam computed tomography showed a palatal soft-tissue mass with thinning of the adjacent cortical plates. A histopathological examination revealed salivary gland tissue with significant acinar destruction, dense lymphocytic infiltration and focal myoepithelial islands. Therefore, BLEL may be considered as a rare differential diagnostic possibility of a palatal soft-tissue mass lesion. Copyright © 2020 Journal of Oral and Maxillofacial Pathology.Adenoid cystic carcinoma (ACC) is a distinct salivary gland neoplasm that predominantly occurs in the minor salivary gland. ACC is an uncommon tumor that progress slowly affecting 5% of paranasal sinuses with high distant metastasis rate in advance stages. This salivary gland tumor is difficult to diagnose both clinically and histopathologically due to its indolent presentation and diverse histopathological patterns. Hence, immunohistochemistry plays a decisive role in diagnosing this tumor. https://www.selleckchem.com/products/rimiducid-ap1903.html A recurrent case of ACC of paranasal sinuses in the maxillary sinus of a 41-year-old female patient without any extraoral abnormality is reported. Copyright © 2020 Journal of Oral and Maxillofacial Pathology.The differential diagnosis of fibro-osseous lesions (FOL) presents oral clinician stomatologists with a challenging task because of their similar clinical, radiographic and histopathological behavior that will also hinder the therapeutic planning. Presentation of case to describe the clinical, radiographic and histopathological features of an unusual case of FOL presented by the patient, a Black woman, and the results obtained with the conservative surgical treatment and 3-month follow-up. The presence of cementum in the histopathological analysis of cemento-osseous dysplasias, according to the current literature, is an important factor for the diagnosis of this lesion. Considering the characteristics presented by this particular case, we could suggest another entity that could be named a benign cemento-osseous lesion with adult onset. Some occurrences, as in the present case, do not fit properly into the current World Health Organization classification, thereby generating some doubts concerning the correct management of these patients. Conservative surgical treatment is the first choice in the management of these lesions due to their self-limiting nature, which show a behavior of clinical involution. Copyright © 2020 Journal of Oral and Maxillofacial Pathology.Focal cemento-osseous dysplasia (FCOD) is a benign fibro-osseous lesion of bone characterized by the replacement of normal bone by fibrous tissue and subsequently followed by its calcification with osseous and cementum-like material. It is mostly asymptomatic in nature and requires no treatment. When secondarily infected, it becomes symptomatic and intervention is required. Here, we report a case of symptomatic FCOD of mandible in a 52-year-old female patient. Histopathological evaluation of the biopsy specimen by ground sections and decalcified sections aided in the final diagnosis of the case. Copyright © 2020 Journal of Oral and Maxillofacial Pathology.