Idebenone (IDE), a synthetic analogue of coenzyme Q10, is able to inhibit lipid peroxidation and detoxify several free radicals. However, because of its poor solubility, it requires ad hoc drug-delivery systems for enhancing its pharmacokinetic properties, preventing undesired cytotoxicity. In this work, NLCs loaded with idebenone (IDE-NLCs) have been prepared. The nanovectors have been physicochemically characterized, and their biological activity has been evaluated on different central nervous system cell lines. IDE-NLCs demonstrated to be stable in water and in cell culture media, and showed a sustained drug release profile. Interestingly, preliminary data demonstrated their ability to permeate an in vitro BBB model. Their protective antioxidant activity in human healthy primary skin fibroblasts and their therapeutic efficacy in ARSACS-derived primary skin fibroblasts have been also investigated, showing their potential for future development as therapeutic agents.Thieno[2,3-f]benzofuran (BDF) has the advantages of a highly planarized structure, strong electron-donating ability, high hole mobility, good conjugation, and a wide spectral response range. https://www.selleckchem.com/products/bay-11-7085.html In recent years, BDF has been widely used in organic solar cells, especially in bulk-heterojunction (BHJ) organic solar cells. In this work, a model molecule PSB-1 was synthesized based on this highly planar fragment and used as a photosensitizer in dye-sensitized solar cells (DSCs), then different aromatic amine donors such as triphenylamine (TPA), carbazole (CZ), and phenothiazine (PTZ) were introduced to the end of PSB-1, and a series of dyes PSB-2, PSB-3, and PSB-4 were designed and synthesized. After that, the relationship among the molecular structure, energy level, and photovoltaic performance of the benzo-[1,2-b4,5-b']dithiophene (BDT) dye was studied by theoretical calculations, photophysics, electrochemistry, and photovoltaic properties. The results show that the introduction of a strong donor can effectively improve the energy level, absorption spectrum, and photovoltaic performance of PSB-1. Through the preliminary test, we found that the energy conversion efficiency (photovoltaic conversion efficiency-PCE) of PSB-4 is up to 5.5%, which is nearly 90% higher than that of PSB-1 (PCE = 2.9%), while the introduction of a weak donor greatly weakens the effect, in which the PCE of PSB-3 is 3.5%, which is only 20% higher than that of the model molecule. By an analysis of the molecular frontier orbital distribution using theoretical calculations, we found that the electron cloud of the highest occupied orbital level (highest occupied molecular orbital-HOMO) of PSB-3 is mainly distributed on the BDF group so that the electron transfer of excited-state molecules mainly occurs from the BDF to the receptor (CA).Simultaneous improvement in the mechanical properties and lifetime of polymer nanocomposites is crucially significant to further extend the versatility of polymer materials and reduce environmental impact. In this study, we fabricated reinforced polypropylene (PP)-based nanocomposites with improved aging stability by the addition of surface-modified well-ordered silica nanospheres with a silane coupling agent (SCA) containing hindered phenol antioxidant as a filler. Uniform grafting of the SCA on the filler surface contributed to homogeneous dispersion of the filler into the matrix, leading to improved properties (e.g., stiffness and ductility) and uniform distribution of the antioxidant component into the entire nanocomposite by filler dispersion. The grafting of SCA also likely provides an inhibitory effect on antioxidant migration, which leads to loss of polymer stability during the aging process. This novel idea for the material design of PP-based nanocomposites, which simultaneously enhances their mechanical properties and lifetime, is promising for application in the fabrication of various types of polymer nanocomposites.Transparent thin films comprising ultralong (within the range 52-387 μm) copper nanowires with diameter ∼7-9 nm encapsulated in amorphous silica have been successfully fabricated using an electrodeposition technique. The length and number density were controlled by electrodeposition time and concentration of precursor materials, respectively. Giant dielectric constant values (∼1010) obtained from these systems were quantitatively explained as a function of the length of the nanowires on the basis of quantum mechanical theory derived by Rice and Bernasconi. These transparent thin films offer a specific capacitance value of 550 F/g with more than 73% cyclic stability over a period of 900 cycles. Our findings demonstrate a facile pathway to control and improve the properties of metal nanowire-based transparent materials for use in supercapacitor applications.Fast thermal response and sensitivity of organic latent heat storage materials with inherent low thermal conductivity to external temperatures is still a challenge in their practical applications. Herein, a shape-stable heat storage material composite, composed of interconnected netlike graphene, hexadecane, and commonly used high-density polyethylene (HDPE), was obtained using a convenient melt blending method. The start melting temperature, melting temperature, and end melting temperature of the obtained shape-stabilized thermal storage materials are presented, indicating that the response rate of the composites to ambient temperature could be indeed increased. This is because the interconnected netlike graphene with high conductivity intercalated into the HDPE matrix provided many conductive pathways for heat transfer. Therefore, the thermal conductivity of the composites is increased to 0.67 W/(m·K), which is about 123% higher than that of pure hexadecane. Meanwhile, the structure of polyethylene and hexadecane is similar, and hexadecane is uniformly dispersed in polyethylene and perfectly combined with polyethylene, which can effectively prevent the leakage of hexadecane during the phase transition. Thus, the obtained composites may play an important role in thermal management applications such as heat collection, transportation, thermal power conversion, and so forth.