Dogs were more likely to choose the owner if they directed a higher percentage of looking time towards the owner's photograph compared to the stranger's one. In addition, the longer the total viewing time of both photos, the higher the probability that dogs chose the stranger. A main effect of dogs' sex was also obtained, with a higher probability of male dogs choosing the owner's photograph. This study provides direct evidence that dogs are able to recognise their owner's face from photographs. The results imply that motion and three-dimensional information is not necessary for recognition. The findings also support the ecological valence of such stimuli and increase the validity of previous investigations into dog cognition that used two-dimensional representations of faces. The effects of attention may reflect differences at the individual level in attraction towards novel faces or in the recruitment of different face processing mechanisms.Throughout the animal kingdom, antipredator mechanisms are an evolutionary driving force to enable the survival of species classified as prey. Information regarding a predator's location can be determined through chemosensory cues from urine, faeces, visual and/or acoustic signals and anal gland secretions; and in several lab and field-based studies it has been seen that these cues mediate behavioural changes within prey species. These behaviours are often linked to fear and avoidance, which will in turn increase the prey's survival rate. In many studies dogs (Canis lupus familiaris) have been used as a predator species, however, no research has addressed a dog's innate ability to detect predator scents, hence the rationale behind this study. We assessed the innate ability of the untrained domestic dog to detect faecal scents of wild Eurasian brown bear (Ursus arctos arctos) and European lynx (Lynx lynx). The study monitored 82 domestic dogs across the UK and Norway. The dogs were exposed to the two predator faecal scents from Eurasian brown bear and European lynx, a herbivore faecal scent of Eurasian beaver (Castor fiber) and water control. Measurements were taken upon the time spent within a 40 cm radius of each scent and changes in the dog's heart rate when within this 40 cm radius. We found dogs spent a decreased length of time around the predator scents and had an increased heart rate in relation to their basal heart rate. We conclude that dogs can innately sense predator scents of brown bear and lynx and elicit fear towards these odours, as shown through behavioural and physiological changes.Nocturnal insects have remarkable visual capacities in dim light. They can navigate using both the surrounding panorama and celestial cues. Individual foraging ants are efficient navigators, able to accurately reach a variety of goal locations. During navigation, foragers compare the current panoramic view to previously learnt views. In this natural experiment, we observed the effects of large panorama changes, the addition of a fence and the removal of several trees near the nest site, on the navigation of the nocturnal bull ant Myrmecia midas. We examined how the ants' navigational efficiency and behaviour changed in response to changes in ~ 30% of the surrounding skyline, following them over multiple nights. Foragers were displaced locally off-route where we collected initial orientations and homing paths both before and after large panorama changes. We found that immediately after these changes, foragers were unable to initially orient correctly to the nest direction and foragers' return paths were less straight, suggesting increased navigational uncertainty. Continued testing showed rapid recovery in both initial orientation and path straightness.Breast cancer is the most common cancer in women. Although several studies demonstrated cellular apoptosis susceptibility protein (CAS) involved in the development of breast cancer, the underlying mechanisms of CAS regulating cell processes in the breast cancer remain elusive. In the present study, we explored the possible mechanism of CAS in contributing to the cell proliferation in the breast cancer cell line MCF-7. Knockdown of CAS led to the reduction of cell viability and proliferation. Furthermore, cell cycle was arrested in G0/G1 phase after knocking down CAS with the decrease of cyclinD1. In addition, RNA-seq analysis for the CAS knockdown cells demonstrated that total eleven genes were significantly altered (Fold changes > 2). Of note, the expression of cyp24a1 was dramatically increased in the shCAS cells compared to that of shNC cells as well as confirmed by quantitative real-time polymerase chain reaction (qPCR). These observations clarified the previous conflicting results on the cell fates of the breast cells regulated by CAS and provide new insight into the role of CAS in the development of breast cancer.The original version of this article unfortunately contained a mistake.BACKGROUND An elevation of cardiac biomarkers is observed after intense or long-lasting physical activity. However, a recent meta-analysis has suggested that there might be an inverse relationship between duration of exercise and degree of biomarker elevation. The objective of this observational study was to investigate the impact of ultra-marathon (UM) vs. marathon (M) on biomarkers of myocyte necrosis and hemodynamic stress/congestion. METHODS Well-trained endurance athletes were recruited to participate in a 130-km UM and a M run. Troponin I (TnI), creatine kinase (CK), N-terminal pro-brain natriuretic peptide (NT-proBNP), mid-regional pro-adrenomedullin (MR-proADM), and copeptin were measured after both events, respectively. RESULTS Fifteen athletes (14 males, one female) were included. There was no difference in exercise intensity according to the Borg scale (UM 16 [IQR 15-17], M 16 [IQR 14-17]; p = 0.424). Biomarkers of myocyte necrosis both differed significantly with higher levels of TnI (UM 0.056 ng/L [IQR 0.022-0.104), M 0.028 ng/L [IQR 0.022-0.049]; p = 0.016) and CK (UM 6992 U/l [IQR 2886-23038], M 425 U/l [IQR 327-681]; p = 0.001) after UM compared to M. Also, NT-proBNP (UM 723 ng/L [IQR 378-1152], M 132 ng/L [IQR 64-198]; p = 0.001) and MR-proADM (UM 1.012 nmol/L [IQR 0.753-0.975], M 0.877 nmol/L [IQR 0.550-0.985]; p = 0.023) as markers of myocardial congestion were significantly higher after UM. There was a tendency for elevated copeptin levels after M, but did not reach statistical significance (p = 0.078). https://www.selleckchem.com/products/brensocatib.html CONCLUSION Ultra-marathon is associated with higher levels of biomarkers of myocyte necrosis and cardiac congestion compared to marathon, highlighting the impact of exercise duration on the cardiovascular system.