A large randomized controlled trial is required to confirm those findings.The choice of the most appropriate treatment in early-stage glottic cancer with anterior commissure involvement remains controversial. Its therapeutic management is complex because it is a significant prognostic indicator of local control with 37% recurrence, due to the difficulty in establishing tumour extension with understaging of up to 40%, and due to the comparison of results in series on tumours that behave variably as they progress, such as T1a, T1b and T2a with commissure involvement. Furthermore, the complexity of the surgical approach using transoral CO2 laser microsurgery requires surgical skill, appropriate equipment and experience. Aspects to be reviewed in this document are an updated anatomical definition of the anterior commissure, tumour progression based on histopathological studies, usefulness of videostroboscopy and NBI in diagnostic accuracy, validity of imaging tests, oncological results published in series reviews, systematic reviews and meta-analyses, tumour margin treatment and voice evaluation.Finally, by way of a summary, the document includes a series of recommendations for the treatment of these tumours.The coronavirus disease 2019 (COVID-19) pandemic has produced a world-wide collapse of social and economic infrastructure, as well as constrained our freedom of movement. This respiratory tract infection is nefarious in how it targets the most distal and highly vulnerable aspect of the human bronchopulmonary tree, specifically, the delicate yet irreplaceable alveoli that are responsible for the loading of oxygen upon red cell hemoglobin for use by all of the body's tissues. In most symptomatic individuals, the disease is a mild immune-mediated syndrome, with limited damage to the lung tissues. About 20% of those affected experience a disease course characterized by a cataclysmic set of immune activation responses that can culminate in the diffuse and irreversible obliteration of the distal alveoli, leading to a virtual collapse of the gas-exchange apparatus. Here, in Part I of a duology on the characterization and potential treatment for COVID-19, we define severe COVID-19 as a consequence of the ability of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to trigger what we now designate for the first time as a 'Prolific Activation of a Network-Immune-Inflammatory Crisis', or 'PANIC' Attack, in the alveolar tree. In Part II we describe an immunotherapeutic hypothesis worthy of the organization of a randomized clinical trial in order to ascertain whether a repurposed, generic, inexpensive, and widely available agent is capable of abolishing 'PANIC'; thereby preventing or mitigating severe COVID-19, with monumental ramifications for world health, and the global pandemic that continues to threaten it.Heart failure is the leading cause of hospitalization of people aged 60-65 in France, with a rising rate of rehospitalization. https://www.selleckchem.com/products/sulfatinib.html This explains the very high healthcare costs in all Western countries and in the United States. Remote monitoring is one of the avenues being studied to reduce this rate of rehospitalisation it is becoming a reality and should bring about changes in the nursing profession in the years to come.In the fieldwork setting, students often find it difficult to make connections between the care provided and the reasons for it. A committed and pedagogical tutoring program should make them aware of the knowledge they need to acquire to develop relevant clinical reasoning for an appropriate diagnostic approach and therapeutic project.When subjected to potentially traumatic events, adults can develop psychological trauma with varying levels of severity. For preventive and therapeutic purposes, these psychological traumas must be assessed and managed by psychologists and/or psychiatrists who are well trained and experienced in performing these complex professional acts.Advanced nursing practice is now established in French law. Master's degree courses in nursing exist in several universities and the first advanced practice nurses are entering the field of care with greater autonomy and competence. Nurses working in mobile palliative care teams (MPCT) have carried out research to clarify the nursing position in MPCT. Although little is known, support for healthcare teams is considered to be the backbone of the nursing role in MPCT.Female genital mutilation (FGM) is a very ancient mutilation practice that still exists today for millions of girls and women around the world. In France, it is illegal. Since twenty-five years, a surgical reconstruction method offered to women who wish to undergo it. They are monitored physiologically, psychologically and socially before, during and after the operation. Interview with Dr. Pierre Foldès, co-founder and president of Women Safe, urological surgeon who invented this surgery.Located on the premises of a hospital in the Paris region, the Women Safe Institute provides free, confidential and caring care, respecting physical and psychological integrity and guaranteeing equal access and treatment for all women and children who are victims of violence. The Women Safe team is multi-professional and offers comprehensive support covering medical, psychological, legal and social issues. Clitoral repair is part of a pre- and post-operative psychological care programme that can be offered to women who have undergone excision, as in the case of Djenaba.New technologies can effectively support care teams, for the well-being of the patient and to take into account his anxieties in particular. Thus virtual reality can be a good solution to reduce the ever-increasing doses of anxiolytics, their side effects and thus reduce hospitalization costs due to increased monitoring.Pain is the main complaint during an emergency room visit. Whether it is a reason in itself or associated with other symptoms, its management determines the proper course of care. They are also potentially a source of new pain, or added strain for the patient, relatives and caregivers. The nurse organizing the reception area prioritizes the passage of patients according to their potential seriousness. The pain assessment is part of this evaluation, renewed during the time of treatment with anticipated analgesia protocols.