To investigate three MR pulse sequences under high-frequency noninvasive ventilation (HF-NIV) at 3 T and determine which one is better-suited to visualize the lung parenchyma. A 3D ultra-short echo time stack-of spirals Volumetric Interpolated Breath-hold Examination (UTE Spiral VIBE), without and with prospective gating, and a 3D double-echo UTE sequence with spiral phyllotaxis trajectory (3D radial UTE) were performed at 3 T in ten healthy volunteers under HF-NIV. Three experienced radiologists evaluated visibility and sharpness of normal anatomical structures, artifacts assessment, and signal and contrast ratio computation. The median of the three readers'scores was used for comparison, p < .05 was considered statistically significant. Incidental findings were recorded and reported. The 3D radial UTE resulted in less artifacts than the non-gated and gated UTE Spiral VIBE in inferior (score  = 3, slight artifact without blurring vs. score  = 2, moderate artifact with blurring of anatomical struVIBE that might be due to better peripheral vasculature visibility, and requires confirmation in a larger cohort. To evaluate the performance of novel spiral MRSI and tissue segmentation pipeline of the brain, to investigate neurometabolic changes in normal-appearing white matter (NAWM) and white matter lesions (WML) of stable relapsing remitting multiple sclerosis (RRMS) compared to healthy controls (HCs). Spiral 3D MRSI using LASER-GOIA-W [16,4] was undertaken on 16 RRMS patients and 9 HCs, to acquire MRSI data from a large volume of interest (VOI) 320cm and analyzed using LCModel. MRSI data and voxel tissue segmentation were compared between the two cohorts using t-tests. Support vector machine (SVM) was used to classify tissue types and assessed by accuracy, sensitivity and specificity. Compared to HCs, RRMS demonstrated a statistically significant reduction in all mean brain tissues and increase in CSF volume. Within VOI, WM decreased (-10%) and CSF increased (41%) in RRMS compared to HCs (p<0.001). MRSI revealed that total creatine (tCr) ratios of N-acetylaspartate and glutamate+glutamine in WML were significantly lower than NAWM-MS (-9%, -8%) and HCs (-14%, -10%), respectively. Myo-inositol/tCr in WML was significantly higher than NAWM-MS (14%) and HCs (10%). SVM of MRSI yielded accuracy, sensitivity and specificity of 86%, 95%, and 70%, respectively for HCs vs WML, which were higher than HC vs NAWM and WML vs NAWM models. This study demonstrates the benefit of MRSI in evaluating MS neurometabolic changes in NAWM. SVM of MRSI data in the MS brain may be suited for clinical monitoring and progression of MS patients. Longitudinal MRSI studies are warranted. This study demonstrates the benefit of MRSI in evaluating MS neurometabolic changes in NAWM. SVM of MRSI data in the MS brain may be suited for clinical monitoring and progression of MS patients. Longitudinal MRSI studies are warranted. Feature tracking (FT) has emerged as a promising method to quantify myocardial strain using conventional cine magnetic resonance imaging (MRI). https://www.selleckchem.com/products/rhapontigenin.html Extracellular volume fraction (ECV) by T1 mapping enables quantification of myocardial fibrosis. To date, the correlation between FT-derived left ventricular strain and ECV has not been elucidated yet. The aim of this study was to evaluate the relationship between myocardial strain by FT and ECV by T1 mapping in patients with non-ischemic dilated cardiomyopathy (NIDCM). A total of 57 patients with NIDCM (61±12years; 46 (81%) male)) and 15 controls (62±11years; 11 (73%) male)) were studied. Using a 1.5T magnetic resonance scanner, pre- and post- T1 mapping images of the LV wall at the mid-ventricular level were acquired to calculate the ECV by a modified Look-Locker inversion recovery (MOLLI) sequence. The radial strain (RS), circumferential strain (CS), and longitudinal strain (LS) were assessed by the FT technique. The ECV and myocardial strain were compared usintion of myocardial fibrosis without any contrast media. In patients with NIDCM, significant correlation was found between myocardial strain and ECV, suggesting the FT-derived myocardial strain might be useful as a non-invasive imaging marker for the detection of myocardial fibrosis without any contrast media.SSFP-based fMRI techniques, known for their high specificity and low geometrical distortion, look promising for high-resolution brain mapping. Nevertheless, they suffer from lack of speed and sensitivity, leading them to be exploited mostly in high-field scanners. Radial acquisition can help with these inefficiencies through better tSNR and more effective coverage of the spatial frequencies. Here, we present a SSFP-fMRI approach and experimentally investigate it at 3 T scanners using radial readout for acquisition. In particular, the visual activity is mapped through three bSSFP techniques 1- Cartesian, 2- Radial with re-gridding reconstruction, 3- Radial with Polar Fourier Transform (PFT) reconstruction. In the PFT technique streaking artifacts, generated at high acceleration rates by re-gridding reconstruction, are avoided and pixel size in the final framework is retrospectively selectable. General agreement, but better tSNR of Radial reading, was first confirmed for these techniques in detection of neural activities at 2 × 2 mm2 in-plane resolution for all 28 subjects,. Next the outcome of the PFT algorithm with 1 × 1 mm2 pixel size was compared to images reconstructed by re-gridding (from the same raw data) with the identical pixel size through interpolation. The localization of the activity showed improvement in PFT over interpolation both qualitatively (i.e., well-fitting in gray-matter) and quantitatively (i.e., higher z-scores and tSNR). The proposed technique can therefore be considered as a remedy for lack of speed and sensitivity in SSFP-based fMRI, in conventional field strengths. The proposed approach is particularly useful in task-based studies when we concentrate on a ROI considerably smaller than FOV, without sacrificing spatial resolution. The multi-compartment diffusion MRI using the spherical mean technique (SMT) has been suggested to enhance the pathological specificity to tissue injury in multiple sclerosis (MS) imaging, but its accuracy and precision have not been comprehensively evaluated. A Cramer-Rao Lower Bound method was used to optimize an SMT protocol for MS imaging. Finite difference computer simulations of spins in packed cylinders were then performed to evaluate the influences of five realistic pathological features in MS lesions axon diameter, axon density, free water fraction, axonal crossing, dispersion, and undulation. SMT derived metrics can be biased by some confounds of pathological variations, such as axon size and free water fraction. However, SMT in general provides valuable information to characterize pathological features in MS lesions with a clinically feasible protocol. SMT may be used as a practical MS imaging method and should be further improved in clinical MS imaging. SMT may be used as a practical MS imaging method and should be further improved in clinical MS imaging.