It appears to be a very effective alternative to combination products suitable for a wide range of users. In our review article we focused on the circulating HPV DNA and its potential role in the pathogenesis of cervical cancer and in the evaluation of patients´ prognosis with cervical cancer Design The article is a systematic review study analyzing available scientific articles focused on the circulating HPV DNA. Clinic of Obstetrics and Gynecology, Jesenius faculty of Medicine in Martin, Comenius University in Bratislava, Slovakia. In our study we searched the medical database PubMed with the key words circulating HPV DNA, cervical cancer, cervical precanceroses. The core of our work is focused on the scientific articles published in English language since year 1995. We identified 13 studies in PubMed database analyzing the circulating HPV DNA in the process of cervical carcinogenesis. It is clear from the results that circulating HPV DNA is a significant prognostic marker of cervical malignant diseases including the early stages. The results focused on circulating HPV DNA show the significance of molecular biology in assessing the prognosis of cervical cancer. This idea has to be supported by further relevant studies. The uniformity of studies and use of the most sophisticated methods could help to answer the question about the real role of circulating HPV DNA in the process of cervical carcinogenesis and disease progression. The results focused on circulating HPV DNA show the significance of molecular biology in assessing the prognosis of cervical cancer. This idea has to be supported by further relevant studies. The uniformity of studies and use of the most sophisticated methods could help to answer the question about the real role of circulating HPV DNA in the process of cervical carcinogenesis and disease progression. Review of current knowledge about particular neutrophil subsets and their role in preeclampsia. Review. Institute of Immunology and Microbiology, First Faculty of Medicine Charles University and General University Hospital in Prague. Preeclampsia represents one of the major complications of pregnancy with high mortality nowadays. Preeclampsia is a multifactorial disease and to this date, there has not been clear disease trigger identified. Throughout preeclampsia development, an increase in pathophysiological inflammatory response is being present. The induction of inflammation leads to higher number of migrating neutrophils. Current studies demonstrate that neutrophils are a rather heterogeneous population. Deregulation of the ratio between immunoregulatory subpopulations, including polymorphonuclear myeloid-derived suppressor cells, and proinflammatory neutrophil subpopulations could contribute to the induction of inflammatory environment at the feto-maternal interface and subsequently could promote development of pregnancy complications, such as preeclampsia. In this review, topic of preeclampsia is briefly introduced and a list of distinct neutrophil subsets published in literature is presented. Unravelling the role of abnormal neutrophil subpopulations migrating to the inflammatory environment of preeclamptic placentas and their role in preeclampsia development could help to identify possible therapeutic targets. Unravelling the role of abnormal neutrophil subpopulations migrating to the inflammatory environment of preeclamptic placentas and their role in preeclampsia development could help to identify possible therapeutic targets. To present a case of a patient who was treated for a sterility at the age of 46. The treatment was successful, after that we confirmed a clinical pregnancy. We present the treatment procedure in this case and summarize other treatment options in patiens over 40 years of age. Case report. The Department of Obstetrics and Gynaecology, 1st Faculty of Medicine, Charles University and the General Faculty Hospital Prague 2. Infertility treatment in patiens over 40 years is often without the desired result, it is often difficult for both the patient and the attending physician. We describe the case in which a patient became pregnant using her own oocytes obtained from a puncture from the native IVF cycle. Treatment management in patients over forty years of age offers several options, above all it is necessary to choose a couple whether they want to undergo treatment with their own or donated oocytes. Pregnancy in patiens over 40 years of age using treatment with thein own oocytes is significantly less successful. There is also a decrease in the chances of a continuing physiologically progressing pregnancy and the birth of a healthy offspring, compared to younger patients. We recommend spreading this information to women's awareness. Treatment management in patients over forty years of age offers several options, above all it is necessary to choose a couple whether they want to undergo treatment with their own or donated oocytes. Pregnancy in patiens over 40 years of age using treatment with thein own oocytes is significantly less successful. There is also a decrease in the chances of a continuing physiologically progressing pregnancy and the birth of a healthy offspring, compared to younger patients. We recommend spreading this information to women's awareness. Case description of dissecting uterine leiomyoma with extrauterine extension and infiltration of right parametrium, ureter and bladder wall. Case report. Department of Pathology, Znojmo Hospital. A 64-year-old woman with chronic pelvalgia and loss of renal function of the right kidney due to urinary tract obstruction is presented. https://www.selleckchem.com/products/anlotinib-al3818.html Ultrasound examination, magnetic resonance imaging and computer tomography scan revealed a pelvic tumour affecting the right edge of the uterine wall, the right parametrium, distal part of the right ureter, the right and partially the cranial bladder wall. Due to this finding, hysterectomy, unilateral parametrectomy, partial resection of the bladder wall and resection of the distal part of the ureter was performed. Histology revealed morphologically bland spindle-cell smooth-muscle tumour corresponding to conventional uterine leiomyoma. Tumour necrosis, cellular atypia, vascular invasion or hydropic degeneration were not observed. A final diagnosis of dissecting leiomyoma of the uterus was made.