We showed that the vertically ordered GNR arrays exhibited ∼3 times higher SERS signals than the tilt ordered arrays. The results prove that the polymer end-tethered GNRs can be used as a building block for preparing the tilted 2D arrays with tunable physicochemical properties, which could have a wide range of potential applications in photonics, electronics, plasmonics, etc.Communication between neurons relies on the release of diverse neurotransmitters, which represent a key-defining feature of a neuron's chemical and functional identity. Neurotransmitters are packaged into vesicles by specific vesicular transporters. However, tools for labeling and imaging synapses and synaptic vesicles based on their neurochemical identity remain limited. We developed a genetically encoded probe to identify glutamatergic synaptic vesicles at the levels of both light and electron microscopy (EM) by fusing the mini singlet oxygen generator (miniSOG) probe to an intralumenal loop of the vesicular glutamate transporter-2. We then used a 3D imaging method, serial block-face scanning EM, combined with a deep learning approach for automatic segmentation of labeled synaptic vesicles to assess the subcellular distribution of transporter-defined vesicles at nanometer scale. These tools represent a new resource for accessing the subcellular structure and molecular machinery of neurotransmission and for transmitter-defined tracing of neuronal connectivity.Ternary oxide nanoparticles have attracted much interest because of their intriguing properties, which are not exhibited by binary oxide nanoparticles. However, the synthesis of ternary oxide nanoparticles is not trivial and requires a fundamental understanding of the complicated precursor chemistry that governs the formation mechanism. Herein, we investigate the role of the chemical composition of precursors in the formation of ternary oxide nanoparticles via a combination of mass spectrometry, electron microscopy with elemental mapping, and thermogravimetric analysis. Mn2+, Co2+, and Ni2+ ions easily form bimetallic-oxo clusters with Fe3+ ions with a composition of MFe2O(oleate)6 (M = Mn, Co, Ni). The use of clusters as precursors leads to the successful synthesis of monodisperse metal ferrite nanoparticles (MFe2O4). On the contrary, zinc- or copper-containing complexes are formed independently from iron-oxo clusters in the precursor synthesis. The mixture of complexes without a bimetallic-oxo core yields a mixture of two different nanoparticles. This study reveals the importance of the precursor composition in the synthesis of ternary oxide nanoparticles.Affinity purification coupled to mass spectrometry (AP-MS) is a popular approach for deciphering the architecture of protein interaction networks. Protein lysates (100 μg) are typically required for multistep sample processing in large volumes, which often causes sample loss and reduces the MS analysis sensitivity. Herein, we reported a fully integrated spintip-based AP-MS technology, termed FISAP, for multiplexed and sensitive interactome profiling. The FISAP device can be easily employed for routine use by introducing AP beads into a C18 StageTip. Taking advantage of the switchable functionalization of the C18 matrix by sodium dodecyl sulfate, all the sample preparation steps encompassing peptide or antibody-based AP, reduction, alkylation, tryptic digestion, tandem mass tag (TMT) labeling, and desalting can be performed in a single tip with a benchtop centrifuge in 4 h. Using a biotinylated tyrosine phosphorylated (pTyr) peptide as an affinity ligand, we mapped the pTyr-dependent interactome of the pY191 mn biomedical research and chemical biology.With the explosive development of smart wearable devices, a serious situation that a large amount of energy waste and environmental pollution caused by electronic discarding needs to be solved urgently. Here, as a throwaway waste material, a chewed gum can be reused for the preparation of wearable iontronics simply. A new gum sensor was constructed by regularly stretching a chewed gum in 6 M NaCl aqueous or even a Chinese edible salt solution for increasing the ionic conductivity. This gum sensor can be shaped arbitrarily, and the preparation process is green, pollution-free, with low energy consumption, and repeatable. Herein, this gum sensor can be utilized for real-time human healthcare monitoring effectively (i.e., facial mood changes, finger flexion, long time walking, and continuous ankle movement) and shows a fast response time of 297 ms and a reliable cycling performance in monitoring body motions. Furthermore, the gum sensor (containing edible salt) can act as a signal transmitter for intelligent information encryption and transmission in the light of the international Morse code with excellent repeatability and stability. Hence, this work will greatly possess wide potential application prospects in wearable electronics and information encryption. https://www.selleckchem.com/products/ha15.html This gum sensor also provides a ponderable option in the next generation of artificial intelligence devices, which can address the troubles of material selections in sensor preparation.We designed and synthesized several families of novel amphiphilic fluorescent phosphorus dendron-based micelles showing relevant antiproliferative activities for use in the field of theranostic nanomedicine. Based on straightforward synthesis pathways, 12 amphiphilic phosphorus dendrons bearing 10 protonated cyclic amino groups (generation one), or 20 protonated amino groups (generation two), and 1 hydrophobic chain carrying 1 fluorophore moiety were created. The amphiphilic dendron micelles had the capacity to aggregate in solution using hydrophilic/hydrophobic interactions, which promoted the formation of polymeric micelles. These dendron-based micelles showed moderate to high antiproliferative activities against a panel of tumor cell lines. This paper presents for the first time the synthesis and our first investigations of new phosphorus dendron-based micelles for cancer therapy applications.We report observations of a strong thickness dependence for charge transfer (CT) from MoSe2 to MoS2, as evidenced by transient absorption measurements. By time-resolving CT from MoSe2 monolayers (1Ls) to MoS2 flakes of varying thicknesses, including 1L, bilayer (2L), and trilayer (3L), we find that the CT time is several picoseconds in the 1L-MoSe2/3L-MoS2 heterostructure, which is much longer than that of 1L-MoSe2/1L-MoS2 and 1L-MoSe2/2L-MoS2 heterostructures. In addition, the recombination lifetime of the interlayer excitons in the 1L/3L heterostructure is several times longer than that of 1L/1L and 1L/2L heterostructures, reaching 800 ps. Furthermore, we show that a prepulse can reduce the CT time and enhance the interlayer exciton recombination in the 1L/3L heterostructure. These findings illustrate that layer thickness can be an important parameter to control the CT property of van der Waals heterostructures. These experimental results also provide important information for further refining the understanding of the physical mechanisms of CT in van der Waals heterostructures.