The hypersensitive detection of metal ions and amino acid becomes more important for environmental and human physical conditions monitor but remains still a great challenge. In this work, we have reported a green and straight forward procedure (solvothermal treatment) for the synthesis of N-doped hemicellulose-based carbon quantum dots (N-H-CQDs) used as an "off-on" fluorescence sensor for ultrasensitive detecting Ag+ ion and L-Cysteine (L-Cys). During this process, hemicellulose used as carbon source and nitrogen-rich deep eutectic solvent (DES) of choline chloride/urea acted as both solvent and doping agent. The prepared N-H-CQDs displayed narrow diameter ranging from 2 to 8 nm with relatively higher quantum yield (QY) of 23.45%. This probe was able to selectively detect Ag+ ion on account of the formation of N-H-CQDs- Ag+ complex and possessed extremely low detection limit of 21 nM. Additionally, the fluorescence of N-H-CQDs-Ag+ complex was restored by the addition of L-Cysteine as Ag+ ion would assemble a more stable Ag+-L-Cysteine complex through Ag+-thiol bonds. Accordingly, the N-H-CQDs-Ag+ solution behaved as secondary fluorescent probe to detect L-Cys in the dynamic range of 0-100 μM with a LOD of 242 nM. The prepared N-H-CQDs are promising probes for hypersensitive detection of Ag+ and L-Cys. V.2-Hydroxyethyl cellulose graft polylactic acid copolymer (HLAC) was prepared by graft copolymerization of lactic acid (LA) and 2-hydroxyethyl cellulose (2-HEC), initiated by dibutyltin dilaurate (DBTDL) catalyst in aqueous media. Halloysite nanotubes (HNTs)/polyurethane (PU) bionanocomposites were prepared using the HLAC as chain extender in the step-growth polymerization. HNTs were dispersed in HLAC based PU matrix at different weight ratios of 0.30, 0.50, 1.00, and 3.00. Chemical structure and morphology of the graft copolymer and bionanocomposite elastomers were characterized using solid state 1H NMR, ATR-FTIR, XRD, and SEM-EDX, while thermal degradation behavior was studied by TGA and DSC techniques. Surface morphology of the HNTs reinforced HLAC/PU bio-nanocomposites demonstrated the homogeneous dispersion of HNTs with little wavy rough surface at low contents which turned to be brittle at higher contents due to agglomerated HNTs. It is observed that the lower contents of HNTs were completely exfoliated in the HLAC/PU matrix. Crystalline pattern of the elastomers improved at lower contents of HNTs that enhanced the thermal stability of the bionanocomposites. The mechanical testing suggested that HNTs/HLAC/PU bionanocomposites have higher values of tensile strength and % elongation with only 0.3-0.5 wt% contents of HNTs that suggested the potential applications of elastomers at economic cost. Calf thymus polypeptide (CTP) is prepared from calf thymus. It has a molecular mass of less then 10 kilodalton (kDa) and contains 17 types of amino acids. This study investigated the hematopoietic function-improvement effect of CTP in CHRF, K562, and bone marrow mononuclear cells; mice with immunosuppression; and with hematopoietic dysfunction. In mice with immunosuppression, CTP enhanced the cytotoxic activity of natural killer cells and the proliferation of lymphocytes and regulated the levels of immunoglobulins. It also enhanced the proliferation and differentiation of CHRF and K562 cells by upregulating the expression of proliferation- and differentiation-related proteins. In mice with hematopoietic dysfunction, CTP restored white blood cell, neutrophil, and hemoglobin proportions in the peripheral blood and enhanced the levels of B lymphocytes and hematopoietic stem cells and progenitor cells in the bone marrow. CTP effectively regulated the levels of hematopoiesis-related cytokines, such as granulocyte colony-stimulating factor (G-CSF), macrophage colony-stimulating factor (M-CSF), interleukin 2, and interferons-γ, and enhanced the expression of hematopoiesis-related proteins in both primary bone marrow cells and mice with hematopoietic dysfunction. These results indicate that CTP has hematopoietic function-improvement effect and this effect may be related to the modulation of colony-stimulating factors (CSFs) and related signaling pathways. V.OBJECTIVE To determine the effect of a training program using simulation-based mastery learning on the performance of residents in pediatric intubations with videolaryngoscopy. METHOD Retrospective cohort study carried out in a tertiary pediatric hospital between July 2016 and June 2018 evaluating a database that included the performance of residents before and after training, as well as the outcome of tracheal intubations. https://www.selleckchem.com/products/dansylcadaverine-monodansyl-cadaverine.html A total of 59 pediatric residents were evaluated in the pre-training with a skills' checklist in the scenario with an intubation simulator; subsequently, they were trained individually using a simulator and deliberate practice in the department itself. After training, the residents were expected to have a minimum passing grade (90/100) in a simulated scenario. The success of the first attempted intubation, use of videolaryngoscopy, and complications in patients older than 1year of age during the study period were also recorded in clinical practice. RESULTS Before training, the mean grade was 77.5/100 (SD 15.2), with only 23.7% (14/59) of residents reaching the minimum passing grade of 90/100. After training, 100% of the residents reached the grade, with an average of 94.9/100 (SD 3.2), p less then 0.01, with only 5.1% (3/59) needing more practice time than that initially allocated. The success rate in the first attempt at intubation in the emergency department with videolaryngoscopy was 77.8% (21/27). The rate of adverse events associated with intubations was 26% (7/27), representing a serious event. CONCLUSIONS Simulation-based mastery learning increased residents' skills related to intubation and allowed safe tracheal intubations with video laryngoscopy. OBJECTIVE Irritable bowel syndrome is a frequent functional gastrointestinal disorder. The aims of this study were to investigate its epidemiology, focusing on the role of intestinal mucosal integrity and to evaluate the impact on the quality of life. METHODS A community-based survey applying a comparative cross sectional approach was conducted in six high schools in Palembang. Subjects were recruited using multistage random sampling divided in two groups. Rome III criteria were used to establish a diagnosis of IBS in combination with a questionnaire to determine risk factors. Determination of fecal alpha-1-antitrypsin and calprotectin levels was performed to determine impaired intestinal mucosal integrity. A questionnaire was used to evaluate how quality of life was affected by irritable bowel syndrome. RESULTS The survey was performed in 454 14-18years old adolescents, of whom 30.2% fulfilled the Rome III criteria for IBS, with the following subtypes 36.5% diarrhea, 18.9% constipation, 21.9% mixed, and 22.6% unclassified.