Chronic lymphocytic leukemia (CLL) is the most common type of adult leukemia. Chromosomal abnormalities are reported to play important roles in CLL pathogenesis and evolution, including deletions of 11q, 13q, 17p, and trisomy12, that are frequently observed and have a known prognostic value. Furthermore, the mutational status of the IGHV gene was reported as an independent prognostic marker in CLL impacting the choice of therapy. We herein, report an unusual presentation of a Lebanese CLL patient with two cytogenetic abnormalities trisomy 12 and t(14;18)(q32;q21), along with an unmutated IGHV, displaying a favorable response to ibrutinib with a maintained complete remission.Major disease complications for patients with essential thrombocythemia (ET) include thrombosis and fibrotic or leukemic transformation. Calreticulin (CALR) mutation type 1 frequencies in ET are estimated between 7% and 11% and ET patients carrying CALR type 1 mutation are associated with lower risk of thrombosis but higher risk of myelofibrosis transformation compared to ET patients with JAK2 mutation. Leukemic transformation rates at 20 years are estimated at less than 5% for ET and risk factors for leukemic transformation are advanced age, thrombosis history, leukocytosis, and anemia. Amongst the subtypes of blast phase myeloproliferative neoplasms, acute promyelocytic leukemia is extremely rare. Herein, we present a case of a promyelocytic blast crisis of post-ET myelofibrosis with associated life-threatening splanchnic vein thrombosis. This case suggests that inflammation plays a key role in thrombotic events and fibrotic/leukemic transformation in ET patients, regardless the molecular landscape.This study was aimed to assess the prevalence and factors associated with second hand smoking (SHS) and tobacco use among pregnant women in Yatinuwara Medical Officer of Health area in Kandy district, Sri Lanka. This was a descriptive cross-sectional study using 390 pregnant women. Data were collected through a pre-tested, self-administered questionnaire. Fifty-four-point four percent were exposed to the SHS. Prevalence of smoking during pregnancy was 0.5% and eight women used smokeless tobacco (SLT). SHS was significantly associated with the age of the mother and family income. Women's age, monthly income, husband's education, husband's occupation, women's age at marriage and trimester of pregnancy were significantly associated with tobacco use. In conclusions, prevalence of SHS was high but tobacco use was low in pregnant women. An effective training program should be designed to educate pregnant women as well as their husbands on adverse effects of tobacco use and SHS during pregnancy.In some clinical situations, the installation of four or more dental implants may be infeasible. Therefore, the installation of protocol-type prostheses with only three implants may be necessary. The mechanical failures can hinder the success of the rehabilitation treatment. To evaluate and compare the mechanical stress of the metallic prosthetic bar when installed over protocol-type prostheses of three and four implants, and to evaluate the stress on the dental implants. Two three-dimensional human jaw models were created. In one model, four dental implants (P4) were designed and in the other model three dental implants (P3) were designed. In both models, according to the arrangement of the dental implants, prosthetic bars were designed. In a finite element analysis software, compressive forces were applied to the ends of both prosthetic bars, simulating the force application during mastication. Tension and stress dissipation were analyzed on the prosthetic bar and dental implants. Both P4 and P3 protocol-type prostheses supported the force efficiently without breaking the bar or the implants. Force dissipation along the bar was more homogeneous in the P3 prosthetic bar than in P4. In addition, P3 implants received a higher concentration of stress in relation to P4 implants. Prosthetic bars and dental implants withstand the stress of load application in both four and three implant protocol-type prostheses. Three-implants protocol showed more satisfactory force dissipation than the four-implant protocol. Prosthetic bars and dental implants withstand the stress of load application in both four and three implant protocol-type prostheses. Three-implants protocol showed more satisfactory force dissipation than the four-implant protocol. Odontogenic Keratocysts (OKCs) are known for their rapid growth and tendency to invade the adjacent tissues. https://www.selleckchem.com/products/17-AAG(Geldanamycin).html Its high recurrence rate (2.5%-62%) has attracted many kinds of research to identify new parameters to predict recurrence that would enable better treatment outcomes for such patients. The present study aims to correlate Sub-Epithelial Hyalinization (SEH) that has not been explored in an Asian population to date and other histopathologic features of OKC to its recurrence propensity. A total of 60 OKCs were analyzed for histopathologic correlation of thickness of lining, complete/incomplete lining, corrugated surface, ortho/para keratinization, intercellular edema, reversed polarity, basilar hyperplasia, the palisading arrangement of basal cells, presence/absence of rete pegs, folding of the epithelium, epithelial/connective tissue separation, SEH, basal offshoots, daughter cysts and inflammation with recurrence to arrive at the most significant histologic feature predicting recurrence. The most significant histologic parameter differentiating recurrent and non-recurrent OKCs was the presence of SEH (p = 0.004), incomplete lining epithelium (p​=​0.023), and a corrugated surface (p​=​0.049). Several other histologic parameters evaluated did not statistically correlate with recurrence, this can be attributed to the smaller sample size considered in the present study. SEH is a reliable histologic parameter to predict recurrence in OKCs. The presence of SEH is indicative of a higher recurrence potential in OKCs. Evaluation of histological parameters and their correlation with recurrence in OKCs on a larger sample size could validate the results of the current study undertaken and potentially unravel more insights on predicting recurrence. Sub-epithelial hyalinization is a significant feature for predicting recurrence in OKC. Sub-epithelial hyalinization is a significant feature for predicting recurrence in OKC.