Here, we introduce ITEXT-BIO, an intelligent process for biomedical domain terminology extraction from textual documents and subsequent analysis. The proposed methodology consists of two complementary approaches, including free and driven term extraction. The first is based on term extraction with statistical measures, while the second considers morphosyntactic variation rules to extract term variants from the corpus. The combination of two term extraction and analysis strategies is the keystone of ITEXT-BIO. These include combined intra-corpus strategies that enable term extraction and analysis either from a single corpus (intra), or from corpora (inter). We assessed the two approaches, the corpus or corpora to be analysed and the type of statistical measures used. Our experimental findings revealed that the proposed methodology could be used (1) to efficiently extract representative, discriminant and new terms from a given corpus or corpora, and (2) to provide quantitative and qualitative analyses on these terms regarding the study domain.Coordination complexes and polymers are central in inorganic and materials chemistry as a variety of metal centers and coordination geometries lead to a diverse range of interesting properties. https://www.selleckchem.com/products/ipa-3.html Here, size and structure control of gem-like quality monocrystals is demonstrated at room temperature. Using the same set of precursors, the copper-to-melamine molar ratio is adjusted to synthesize either a novel coordination complex of dinuclear copper and melamine (Cu2M1), or a barely-studied coordination polymer of zigzag copper-chlorine chains (Cu4M1). Crystals of the former are dark green and square with a size up to 350 μm across. The latter is light green, octagonal, and as large as 5 mm across. The magnetic properties of both crystals reflect the low-dimensional arrangements of copper. The magnetic susceptibility of Cu2M1 is modelled with a spin-1/2 dimer, and that of Cu4M1 with a spin-1/2 one-dimensional Ising chain. Controlled synthesis of such quality magnetic crystals is a prerequisite for various magnetic and magneto-optical applications.On-surface synthesis provides a powerful approach toward the atomically precise fabrication of π-conjugated ladder polymers (CLPs). We report herein the surface-assisted synthesis of nonbenzenoid CLPs from cyclopenta-annulated anthracene monomers on Au(111) under ultrahigh vacuum conditions. Successive thermal annealing steps reveal the dehalogenative homocoupling to yield an intermediate 1D polymer and the subsequent cyclodehydrogenation to form the fully conjugated ladder polymer. Notably, neighbouring monomers may fuse in two different ways, resulting in six- and five-membered rings, respectively. The structure and electronic properties of the reaction products have been investigated via low-temperature scanning tunneling microscopy and spectroscopy, complemented by density-functional theory calculations. Our results provide perspectives for the on-surface synthesis of nonbenzenoid CLPs with the potential to be used for organic electronic devices.The introduction of foreign cargo into living cells with high delivery efficiency and cell viability is a challenge in cell biology and biomedical research. Here, we demonstrate a nanosecond pulse laser-activated photoporation for highly efficient intracellular delivery using titanium dioxide (TiO2) microspikes as a substratum. The TiO2 microspikes were formed on titanium (Ti) substrate using an electrochemical anodization process. Cells were cultured on top of the TiO2 microspikes as a monolayer, and the biomolecule was added. Due to pulse laser exposure of the TiO2 microspike-cell membrane interface, the microspikes heat up and induce cavitation bubbles, which rapidly grow, coalesce and collapse to induce explosion, resulting in very strong fluid flow at the cell membrane surface. Thus, the cell plasma membrane disrupts and creates transient nanopores, allowing delivery of biomolecules into cells by a simple diffusion process. By this technique, we successfully delivered propidium iodide (PI) dye in HeLa cells with high delivery efficiency (93%) and high cell viability (98%) using 7 mJ pulse energy at 650 nm wavelength. Thus, our TiO2 microspike-based platform is compact, easy to use, and potentially applicable for therapeutic and diagnostic purposes.Background Nigeria's former Prime Minister, Sir Abubakar Tafawa Balewa, in his addresses of August and October 1, 1960, declared Africa as the centrepiece of Nigeria's foreign policy. This policy thrust has remained a constant variable in the country's diplomatic engagements over the years. The doctrine of Afrocentrism is predicated on the supposed manifest leadership role placed on Nigeria by nature. This made her leaders define Africa's interest as Nigeria's national interest, a development that has been contended to have no empirical bearing on the welfare of Nigerians thereby generating intense scrutiny. Consequently, this study evaluates the impact of Nigeria's Afrocentric foreign policy thrust on the welfare of the ordinary Nigerians. The study further analyses the country's gravitation towards citizen-centred diplomacy in 2007. These will help in comprehending the interaction between national interest and foreign policy in Nigeria, and to identify whose interests have been protected the most in Nigeria's foreign policy pursuit - that of the ordinary citizens or the elites? Methods Through the qualitative research method, in-depth interviews (IDIs) were conducted with Key Informants (KIs) for data collection. Responses from field study are merged with other primary and secondary sources of data to provide an incisive and balanced analysis that is premised on political realism. Results Findings indicate that Nigeria's international generosity and leadership role has never been predicated on a clear vision of national interest. Notwithstanding the flaws in Nigeria's foreign policy over the years, this study also discovered that the outcome has not been a total failure as some respondents maintain. Conclusions With the nation's gravitation towards citizen-centred diplomacy, it is hoped that the country will put the interest of its citizens first in her policy pursuits.