OBJECTIVES Recent studies have suggested that evening blue light exposure is associated with sleep and circadian rhythm abnormalities. This study examined the effect of blue-blocking (BB) glasses on sleep and circadian rhythm in patients with bipolar disorder (BD). METHODS We used a randomized, placebo-controlled, double-blinded design. Outpatients with BD and also with insomnia were randomly assigned to wear either orange glasses (BB) or clear ones (placebo) and were instructed to use these from 2000 hours until bedtime for 2 weeks. The primary outcome metric was the difference in change from baseline to after intervention in sleep quality, as measured by the visual analog scale (VAS). RESULTS Forty-three patients were included in this study (BB group, 21; placebo group, 22). The change in sleep quality as per the VAS metric was not significantly different between the two groups (95% confidence interval [CI], -3.34 to 24.72; P = .13). However, the Morningness-Eveningness Questionnaire score had shifted to an advanced rhythm in the BB group and to a delayed rhythm in the placebo group, and the difference in these changes was statistically significant (95% CI, 1.69-7.45; P = .003). The change in the actigraphy sleep parameters and mood symptoms was not significantly different between the two groups. CONCLUSION Although concurrent medications may have influenced, our results suggest that BB glasses may be useful as an adjunctive treatment for circadian rhythm issues in patients with BD. © 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.OBJECTIVE To reanalyze Aristotle's classic lecture, "On melancholy," with current clinical interpretations METHOD The full lecture is described and interpreted in a new translation. RESULTS Aristotle's lecture has been understood to reflect a claim about a link between genius and madness, or more specifically depression and genius. In fact, his concept of melancholia included what today would be called mania, and thus his lecture really is about manic-depressive illness (MD) and genius. He appears to have been the first ancient thinker (not Aretaeus of Cappadocia) to identify manic and depressive states as part of the same disease. Aristotle claims that MDI is necessary in all persons who become great leaders in politics, great thinkers in philosophy, or great inspired poets or artists. Specifically, he sees the mood states as producing such genius especially when mild as part of mood temperaments (dysthymia, cyclothymia, hyperthymia in modern terms), but also sometimes in full-blown mood disease. Though he makes his argument in the language of humoral theory about black bile, his clinical insights mostly coincide with contemporary empirical data on creativity and leadership. CONCLUSIONS When understood, Aristotle is making a radical claim about MDI, which would have major implications for understanding leadership in particular, and greatness in general. This article is protected by copyright. All rights reserved.AIM To determine the relationship between bone microarchitecture, as measured by trabecular bone score, and advanced glycation end-product accumulation, as assessed by skin autofluorescence. METHODS This was a cross-sectional study. Participants were 64 post-menopausal women with type 2 diabetes and 175 post-menopausal women without diabetes. Trabecular bone score and skin autofluorescence data were obtained at time of bone density measurement. RESULTS Trabecular bone score and skin autofluorescence were inversely correlated in women with type 2 diabetes (r = -0.34, P = 0.006); no correlation was seen in post-menopausal women without diabetes (r = -0.029, P = 0.707). After adjustment, neither skin autofluorescence nor a diagnosis of diabetes were associated with trabecular bone score, but HbA1c and waist circumference were independently associated with trabecular bone score. CONCLUSION Skin autofluorescence did not predict trabecular bone score. In contrast, glycaemia, as reflected by HbA1c , and visceral adiposity, as reflected by waist circumference, were independently associated with trabecular bone score. This article is protected by copyright. All rights reserved.Oral ziprasidone (ziprasidone hydrochloride) has been approved by the U.S. Food and Drug Administration (FDA) in 2001 for the treatment of schizophrenia, and acute manic or mixed episodes associated with bipolar disorder (BPD) with or without psychotic features. Ziprasidone intramuscular (ziprasidone mesylate) is FDA-approved for acute agitation in patients with schizophrenia. This article is protected by copyright. All rights reserved.Keratoacanthoma centrifugum marginatum (KCM) is a very rare variant of Keratoacanthoma, characterized with progressive centrifugal growth, central healing and atrophy. Due to its rarity and lack of distinctive histopathological features, KCM often raises diagnostic and therapeutic challenge. We present a case of a 76- year- old Caucasian woman with a single large tumor on her right shin that responded to oral retinoids. The patient presented history of local trauma. The tumor developed over the course of 20 months from a scar. To the best of our knowledge, this is the fifth case of KCM associated to mechanical trauma as a possible triggering factor. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.The new allele, HLA-DQB1*05247 differs from HLA-DQB1*05020101 by one nucleotide substitution at codon 35. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.We developed a stromal cell-derived factor-1 alpha (SDF-1α)-aligned silk fibroin (SF)/three-dimensional porous bladder acellular matrix graft (3D-BAMG) composite scaffold for long-section ventral urethral regeneration and repair in vivo. SDF-1α-aligned SF microfiber/3D-BAMG, aligned SF microfiber/3D-BAMG, and nonaligned SF microfiber/3D-BAMG scaffolds were prepared using electrostatic spinning and wet processing. Adipose-derived stem cell (ADSC) and bone marrow stromal cell (BMSC) migration was assessed in the SDF-1α-loaded scaffolds. Sustained SDF-1α release in vitro and vivo was analyzed using enzyme-linked immunosorbent assay (ELISA) and western blotting, respectively. The scaffolds were used to repair a 1.5 × 1 cm2 ventral urethral defect in male rabbits in vivo. General observation and retrograde urinary tract contrast assessment were used to examine urethral lumen patency and continuity at 1 and 3 months post-surgery. https://www.selleckchem.com/products/dual-specificity-protein-phosphatase-1-6-Inhibitor-bcl.html Postoperative rehabilitation was evaluated using histological detection. The composite scaffolds sustained SDF-1α release for over 16 days in vitro.